GSK778 (iBET-BD1 dihydrochloride)

Biorbyt

GSK778 (iBET-BD1 dihydrochloride) [2451862-42-1]

10

2451862-42-1

Research Use Only

C30H33N5O3

511.6147

GSK778 (iBET-BD1) is a potent and selective BD1 bromodomain inhibitor of the BET proteins, with IC50s of 75 nM (BRD2 BD1), 41 nM (BRD3 BD1), 41 nM (BRD4 BD1), and 143 nM (BRDT BD1), respectively. GSK778 phenocopies the effects of pan-BET inhibitors in cancer models.

O(C1=C(C2C(C([H])([H])[H])=NOC=2C([H])([H])[H])C([H])=C2C(=C1[H])C1=C(C([H])=N2)N=C(C([H])([H])OC([H])([H])[H])N1[C@]([H])(C([H])([H])[H])C1C([H])=C([H])C([H])=C([H])C=1[H])C([H])([H])[C@]1([H])C([H])([H])N([H])C([H])([H])C1([H])[H]

12352200