IHC-P analysis of human mammary cancer tissue using GTX12288 Hamartin / TSC1 antibody.
IHC-P analysis of human mammary cancer tissue using GTX12288 Hamartin / TSC1 antibody.
Hamartin / TSC1 antibody
GTX12288
ApplicationsWestern Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman, Mouse, Rat
TargetTSC1
Overview
- SupplierGeneTex
- Product NameHamartin / TSC1 antibody
- Delivery Days Customer9
- Application Supplier NoteWB: 0.1-0.5microg/ml. IHC-P: 0.5-1microg/ml. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- ApplicationsWestern Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
- CertificationResearch Use Only
- ClonalityPolyclonal
- Concentration500 ug/ml
- ConjugateUnconjugated
- Gene ID7248
- Target nameTSC1
- Target descriptionTSC complex subunit 1
- Target synonymshamartin; LAM; truncated hemartin; TSC; tuberous sclerosis 1 protein
- HostRabbit
- IsotypeIgG
- Protein IDQ92574
- Protein NameHamartin
- Scientific DescriptionThis gene is a tumor suppressor gene that encodes the growth inhibitory protein hamartin. The encoded protein interacts with and stabilizes the GTPase activating protein tuberin. This hamartin-tuberin complex negatively regulates mammalian target of rapamycin complex 1 (mTORC1) signalling which is a major regulator of anabolic cell growth. This protein also functions as a co-chaperone for Hsp90 that inhibits its ATPase activity. This protein functions as a facilitator of Hsp90-mediated folding of kinase and non-kinase clients, including Tsc2 and thereby preventing their ubiquitination and proteasomal degradation. Mutations in this gene have been associated with tuberous sclerosis. [provided by RefSeq, Apr 2018]
- ReactivityHuman, Mouse, Rat
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203