Hamartin / TSC1 antibody

GeneTex

Hamartin / TSC1 antibody - Overexpression Validated

9

This antibody is expected to recognise isoform 1 (NP_000359.1) only.

WB: 0.1-0.3microg/ml. IHC-P: 3-6microg/ml. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Research Use Only

Polyclonal

0.50 mg/ml

Unconjugated

TSC1

TSC complex subunit 1

hamartin; LAM; truncated hemartin; TSC; tuberous sclerosis 1 protein

Goat

IgG

Hamartin

This gene is a tumor suppressor gene that encodes the growth inhibitory protein hamartin. The encoded protein interacts with and stabilizes the GTPase activating protein tuberin. This hamartin-tuberin complex negatively regulates mammalian target of rapamycin complex 1 (mTORC1) signalling which is a major regulator of anabolic cell growth. This protein also functions as a co-chaperone for Hsp90 that inhibits its ATPase activity. This protein functions as a facilitator of Hsp90-mediated folding of kinase and non-kinase clients, including Tsc2 and thereby preventing their ubiquitination and proteasomal degradation. Mutations in this gene have been associated with tuberous sclerosis. [provided by RefSeq, Apr 2018]

Human

-20°C or -80°C,2°C to 8°C

12352203