HAP1 antibody, Internal

GeneTex

HAP1 antibody, Internal

7

This antibody is expected to recognize all reported isoforms (NP_003940.1, NP_817084.1)

WB: 0.1-0.3microg/ml. IHC-P: 3.75microg/ml. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Research Use Only

Polyclonal

0.50 mg/ml

Unconjugated

HAP1

huntingtin associated protein 1

epididymis secretory sperm binding protein; HAP-1; HAP2; hHLP1; HIP5; HLP; huntingtin-associated protein 1; huntingtin-associated protein 2; neuroan 1

Goat

IgG

Huntingtin-associated protein 1

Huntingtons disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein that interacts with huntingtin, with two cytoskeletal proteins (dynactin and pericentriolar autoantigen protein 1), and with a hepatocyte growth factor-regulated tyrosine kinase substrate. The interactions with cytoskeletal proteins and a kinase substrate suggest a role for this protein in vesicular trafficking or organelle transport. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

Human

-20°C or -80°C,2°C to 8°C

12352203