ProductsBack/HDAC6 antibody [4C5]

ICC/IF analysis of COS7 cells transiently transfected with HDAC6 plasmid using GTX84377 HDAC6 antibody [4C5].

HDAC6 antibody [4C5]

GTX84377

ApplicationsFlow Cytometry, ImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Product group Antibodies

ReactivityCanine, Human, Monkey, Mouse, Rat

TargetHDAC6

Overview

Supplier
GeneTex
Product Name
HDAC6 antibody [4C5]
Delivery Days Customer
9
Application Supplier Note
WB: 1:500-1:2000. ICC/IF: 1:100. IHC-P: 1:150. FACS: 1:100. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Applications
Flow Cytometry, ImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Certification
Research Use Only
Clonality
Monoclonal
Clone ID
4C5
Concentration
0.84 mg/ml
Conjugate
Unconjugated
Gene ID10013
Target name
HDAC6
Target description
histone deacetylase 6
Target synonyms
CPBHM, HD6, JM21, KDAC6, PPP1R90, protein deacetylase HDAC6, E3 ubiquitin-protein ligase HDAC6, alpha-tubulin deacetylase HDAC6, protein phosphatase 1, regulatory subunit 90, tubulin-lysine deacetylase HDAC6
Host
Mouse
Isotype
IgG1
Protein IDQ9UBN7
Protein Name
Protein deacetylase HDAC6
Scientific Description
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity). Plays a central role in microtubule-dependent cell motility via deacetylation of tubulin.
Reactivity
Canine, Human, Monkey, Mouse, Rat
Storage Instruction
-20°C or -80°C,2°C to 8°C
UNSPSC
12352203

References

Lyu J, Li Z, Roberts JP, et al. The short-chain fatty acid acetate coordinates with CD30 to modulate T-cell survival. Mol Biol Cell. 2023,34(8):br11. doi: 10.1091/mbc.E23-01-0032
Read this paper
Huang PY, Shih IA, Liao YC, et al. A novel HDAC11 inhibitor potentiates the tumoricidal effects of cordycepin against malignant peripheral nerve sheath tumor through the Hippo signaling pathway. Am J Cancer Res. 2022,12(2):873-892.
Read this paper
Kim S, Hwang Y, Kang HC. A protocol to visualize cytosolic aggresome-like bodies using confocal microscopy. STAR Protoc. 2021,2(3):100674. doi: 10.1016/j.xpro.2021.100674
Read this paper
Zhang L, Zhang Z, Li C, et al. S100A11 Promotes Liver Steatosis via FOXO1-Mediated Autophagy and Lipogenesis. Cell Mol Gastroenterol Hepatol. 2021,11(3):697-724. doi: 10.1016/j.jcmgh.2020.10.006
Read this paper
Feng CW, Chen NF, Sung CS, et al. Therapeutic Effect of Modulating TREM-1 via Anti-inflammation and Autophagy in Parkinson's Disease. Front Neurosci. 2019,13:769. doi: 10.3389/fnins.2019.00769
Read this paper
Tsai HD, Wu JS, Kao MH, et al. Clinacanthus nutans Protects Cortical Neurons Against Hypoxia-Induced Toxicity by Downregulating HDAC1/6. Neuromolecular Med. 2016,18(3):274-82. doi: 10.1007/s12017-016-8401-2
Read this paper
He Q, Wang G, Wakade S, et al. Primary cilia in stem cells and neural progenitors are regulated by neutral sphingomyelinase 2 and ceramide. Mol Biol Cell. 2014,25(11):1715-29. doi: 10.1091/mbc.E13-12-0730
Read this paper
He Q, Wang G, Dasgupta S, et al. Characterization of an apical ceramide-enriched compartment regulating ciliogenesis. Mol Biol Cell. 2012,23(16):3156-66. doi: 10.1091/mbc.E12-02-0079
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HDAC6 antibody [4C5]

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