Bio-Connect

Hexokinase II antibody

GTX111525
GeneTex
ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
TargetHK2
Sign in to order and to see your custom pricing.
Large volume orders?
Order with a bulk request

Overview

  • Supplier
    GeneTex
  • Product Name
    Hexokinase II antibody
  • Delivery Days Customer
    9
  • Application Supplier Note
    WB: 1:5000-1:20000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    ImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    0.63 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID3099
  • Target name
    HK2
  • Target description
    hexokinase 2
  • Target synonyms
    HKII, HXK2, hexokinase-2, hexokinase type II, hexokinase-2, muscle, hexokinase-B, muscle form hexokinase
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDP52789
  • Protein Name
    Hexokinase-2
  • Scientific Description
    Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. This gene encodes hexokinase 2, the predominant form found in skeletal muscle. It localizes to the outer membrane of mitochondria. Expression of this gene is insulin-responsive, and studies in rat suggest that it is involved in the increased rate of glycolysis seen in rapidly growing cancer cells. [provided by RefSeq]
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • Baryła I, Styczeń-Binkowska E, Płuciennik E, et al. The WWOX/HIF1A Axis Downregulation Alters Glucose Metabolism and Predispose to Metabolic Disorders. Int J Mol Sci. 2022,23(6). doi: 10.3390/ijms23063326
    Read this paper
  • Huang CY, Weng YT, Li PC, et al. Calcitriol Suppresses Warburg Effect and Cell Growth in Human Colorectal Cancer Cells. Life (Basel). 2021,11(9). doi: 10.3390/life11090963
    Read this paper
  • Harada Y, Nakajima K, Suzuki T, et al. Glycometabolic Regulation of the Biogenesis of Small Extracellular Vesicles. Cell Rep. 2020,33(2):108261. doi: 10.1016/j.celrep.2020.108261
    Read this paper
  • Lee YR, Wu SY, Chen RY, et al. Regulation of autophagy, glucose uptake, and glycolysis under dengue virus infection. Kaohsiung J Med Sci. 2020,36(11):911-919. doi: 10.1002/kjm2.12271
    Read this paper
  • Takino JI, Sato T, Nagamine K, et al. The inhibition of Bax activation-induced apoptosis by RasGRP2 via R-Ras-PI3K-Akt signaling pathway in the endothelial cells. Sci Rep. 2019,9(1):16717. doi: 10.1038/s41598-019-53419-4
    Read this paper
  • Lee CH, Kim MJ, Lee HH, et al. Adenine Nucleotide Translocase 2 as an Enzyme Related to [(18)F] FDG Accumulation in Various Cancers. Mol Imaging Biol. 2019,21(4):722-730. doi: 10.1007/s11307-018-1268-x
    Read this paper
  • Yang T, Ren C, Qiao P, et al. PIM2-mediated phosphorylation of hexokinase 2 is critical for tumor growth and paclitaxel resistance in breast cancer. Oncogene. 2018,37(45):5997-6009. doi: 10.1038/s41388-018-0386-x
    Read this paper
  • Huang YP, Chang NW. Proteomic analysis of oral cancer reveals new potential therapeutic targets involved in the Warburg effect. Clin Exp Pharmacol Physiol. 2017,44(8):880-887. doi: 10.1111/1440-1681.12774
    Read this paper