Hexokinase II antibody
GTX111525
ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
TargetHK2
Overview
- SupplierGeneTex
- Product NameHexokinase II antibody
- Delivery Days Customer9
- Application Supplier NoteWB: 1:5000-1:20000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
- CertificationResearch Use Only
- ClonalityPolyclonal
- Concentration0.63 mg/ml
- ConjugateUnconjugated
- Gene ID3099
- Target nameHK2
- Target descriptionhexokinase 2
- Target synonymsHKII, HXK2, hexokinase-2, hexokinase type II, hexokinase-2, muscle, hexokinase-B, muscle form hexokinase
- HostRabbit
- IsotypeIgG
- Protein IDP52789
- Protein NameHexokinase-2
- Scientific DescriptionHexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. This gene encodes hexokinase 2, the predominant form found in skeletal muscle. It localizes to the outer membrane of mitochondria. Expression of this gene is insulin-responsive, and studies in rat suggest that it is involved in the increased rate of glycolysis seen in rapidly growing cancer cells. [provided by RefSeq]
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203
References
- Baryła I, Styczeń-Binkowska E, Płuciennik E, et al. The WWOX/HIF1A Axis Downregulation Alters Glucose Metabolism and Predispose to Metabolic Disorders. Int J Mol Sci. 2022,23(6). doi: 10.3390/ijms23063326Read this paper
- Huang CY, Weng YT, Li PC, et al. Calcitriol Suppresses Warburg Effect and Cell Growth in Human Colorectal Cancer Cells. Life (Basel). 2021,11(9). doi: 10.3390/life11090963Read this paper
- Harada Y, Nakajima K, Suzuki T, et al. Glycometabolic Regulation of the Biogenesis of Small Extracellular Vesicles. Cell Rep. 2020,33(2):108261. doi: 10.1016/j.celrep.2020.108261Read this paper
- Lee YR, Wu SY, Chen RY, et al. Regulation of autophagy, glucose uptake, and glycolysis under dengue virus infection. Kaohsiung J Med Sci. 2020,36(11):911-919. doi: 10.1002/kjm2.12271Read this paper
- Takino JI, Sato T, Nagamine K, et al. The inhibition of Bax activation-induced apoptosis by RasGRP2 via R-Ras-PI3K-Akt signaling pathway in the endothelial cells. Sci Rep. 2019,9(1):16717. doi: 10.1038/s41598-019-53419-4Read this paper
- Lee CH, Kim MJ, Lee HH, et al. Adenine Nucleotide Translocase 2 as an Enzyme Related to [(18)F] FDG Accumulation in Various Cancers. Mol Imaging Biol. 2019,21(4):722-730. doi: 10.1007/s11307-018-1268-xRead this paper
- Yang T, Ren C, Qiao P, et al. PIM2-mediated phosphorylation of hexokinase 2 is critical for tumor growth and paclitaxel resistance in breast cancer. Oncogene. 2018,37(45):5997-6009. doi: 10.1038/s41388-018-0386-xRead this paper
- Huang YP, Chang NW. Proteomic analysis of oral cancer reveals new potential therapeutic targets involved in the Warburg effect. Clin Exp Pharmacol Physiol. 2017,44(8):880-887. doi: 10.1111/1440-1681.12774Read this paper



![FACS analysis of K562 cells using GTX82791 Hexokinase II antibody [3D3]. Green : Hexokinase II Purple : negative control](https://www.genetex.com/upload/website/prouct_img/normal/GTX82791/GTX82791_20170912_FACS_w_23051501_847.webp)
![ICC/IF analysis of COS7 cells transiently transfected with Hexokinase II plasmid using GTX84357 Hexokinase II antibody [4C5].](https://www.genetex.com/upload/website/prouct_img/normal/GTX84357/GTX84357_1054_ICCIF_w_23061420_936.webp)