ProductsBack/HGS antibody [C2C3], C-term

HGS antibody [C2C3], C-term

Name: HGS antibody [C2C3], C-term
SKU: GTX101718_G10
Availability: BackOrder

GTX101718

ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Product group Antibodies

ReactivityHuman, Mouse, Rat

TargetHGS

Overview

Supplier
GeneTex
Product Name
HGS antibody [C2C3], C-term
Delivery Days Customer
9
Application Supplier Note
WB: 1:1000-1:10000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Applications
ImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Certification
Research Use Only
Clonality
Polyclonal
Concentration
1 mg/ml
Conjugate
Unconjugated
Gene ID9146
Target name
HGS
Target description
hepatocyte growth factor-regulated tyrosine kinase substrate
Target synonyms
HRS, hepatocyte growth factor-regulated tyrosine kinase substrate, human growth factor-regulated tyrosine kinase substrate, protein pp110
Host
Rabbit
Isotype
IgG
Protein IDO14964
Protein Name
Hepatocyte growth factor-regulated tyrosine kinase substrate
Scientific Description
The protein encoded by this gene regulates endosomal sorting and plays a critical role in the recycling and degradation of membrane receptors. The encoded protein sorts monoubiquitinated membrane proteins into the multivesicular body, targeting these proteins for lysosome-dependent degradation. [provided by RefSeq]
Reactivity
Human, Mouse, Rat
Storage Instruction
-20°C or -80°C,2°C to 8°C
UNSPSC
12352203

Larios J, Mercier V, Roux A, et al. ALIX- and ESCRT-III-dependent sorting of tetraspanins to exosomes. J Cell Biol. 2020,219(3). doi: 10.1083/jcb.201904113
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Quinney KB, Frankel EB, Shankar R, et al. Growth factor stimulation promotes multivesicular endosome biogenesis by prolonging recruitment of the late-acting ESCRT machinery. Proc Natl Acad Sci U S A. 2019,116(14):6858-6867. doi: 10.1073/pnas.1817898116
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Chou SF, Tsai ML, Huang JY, et al. The Dual Role of an ESCRT-0 Component HGS in HBV Transcription and Naked Capsid Secretion. PLoS Pathog. 2015,11(10):e1005123. doi: 10.1371/journal.ppat.1005123
Read this paper
Kurgonaite K, Gandhi H, Kurth T, et al. Essential role of endocytosis for interleukin-4-receptor-mediated JAK/STAT signalling. J Cell Sci. 2015,128(20):3781-95. doi: 10.1242/jcs.170969
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Kristensen AR, Gsponer J, Foster LJ. A high-throughput approach for measuring temporal changes in the interactome. Nat Methods. 2012,9(9):907-9. doi: 10.1038/nmeth.2131
Read this paper