Bio-Connect

HIF1AN Polyclonal Antibody

RD83322A
Reddot Biotech
TargetHIF1AN
Product group Antibodies
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Overview

  • Supplier
    Reddot Biotech
  • Product Name
    HIF1AN Polyclonal Antibody
  • Delivery Days Customer
    5
  • Concentration
    1 mg/ml
  • Gene ID55662
  • Target name
    HIF1AN
  • Target description
    hypoxia inducible factor 1 subunit alpha inhibitor
  • Target synonyms
    factor inhibiting HIF1; factor inhibiting HIF-1; FIH1; FIH-1; hypoxia inducible factor 1 alpha subunit inhibitor; hypoxia-inducible factor 1-alpha inhibitor; hypoxia-inducible factor asparagine hydroxylase; peptide-aspartate beta-dioxygenase
  • Scientific Description
    Factor inhibiting HIF-1 (FIH-1) exists as a homodimer and binds to HIF-1alpha. Specifically, FIH-1 operates as an asparaginyl hydroxylase. It catalyzes the hydroxylation of the beta-carbon of Asparagine residue 803 within the carboxy terminal transactivation domain of HIF-1alpha. This hydroxylation event blocks the association of HIF-1alpha with co-activators. FIH-1 also binds to von Hippel-Lindau (VHL) tumor suppressor protein, which represses transcriptional ac-tivity of HIF-1alpha. In transiently transfected human osteosarcoma cells, FIH-1 localizes to the cytoplasm.
  • Storage Instruction
    -20°C
  • UNSPSC
    12352203