HIF1AN Polyclonal Antibody

Reddot Biotech

HIF1AN Polyclonal Antibody

5

ImmunoFluorescence, ImmunoHistoChemistry

Research Use Only

1 mg/ml

Unconjugated

HIF1AN

hypoxia inducible factor 1 subunit alpha inhibitor

FIH1, hypoxia-inducible factor 1-alpha inhibitor, FIH-1, factor inhibiting HIF-1, factor inhibiting HIF1, hypoxia inducible factor 1 alpha subunit inhibitor, hypoxia-inducible factor asparagine hydroxylase, peptide-aspartate beta-dioxygenase

Rabbit

IgG

Factor inhibiting HIF-1 (FIH-1) exists as a homodimer and binds to HIF-1alpha. Specifically, FIH-1 operates as an asparaginyl hydroxylase. It catalyzes the hydroxylation of the beta-carbon of Asparagine residue 803 within the carboxy terminal transactivation domain of HIF-1alpha. This hydroxylation event blocks the association of HIF-1alpha with co-activators. FIH-1 also binds to von Hippel-Lindau (VHL) tumor suppressor protein, which represses transcriptional ac-tivity of HIF-1alpha. In transiently transfected human osteosarcoma cells, FIH-1 localizes to the cytoplasm.

-20°C

12352203