HIPPI antibody [4F6]

GeneTex

HIPPI antibody [4F6]

9

WB: 1:2000. ICC/IF: 1:100. IHC-P: 1:50. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

ImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Research Use Only

Monoclonal

4F6

1 mg/ml

Unconjugated

IFT57

intraflagellar transport 57

ESRRBL1, HIPPI, MHS4R2, OFD18, intraflagellar transport protein 57 homolog, HIP1 protein interactor, HIP1-interacting protein, dermal papilla-derived protein 8, estrogen-related receptor beta like 1, estrogen-related receptor beta-like protein 1, huntingtin interacting protein-1 interacting protein, intraflagellar transport 57 homolog

Mouse

IgG1

Intraflagellar transport protein 57 homolog

Required for the formation of cilia. Plays an indirect role in sonic hedgehog signaling, cilia being required for all activity of the hedgehog pathway (By similarity). Has pro-apoptotic function via its interaction with HIP1, leading to recruit caspase-8 (CASP8) and trigger apoptosis. Has the ability to bind DNA sequence motif 5-AAAGACATG-3 present in the promoter of caspase genes such as CASP1, CASP8 and CASP10, suggesting that it may act as a transcription regulator - however the relevance of such function remains unclear.

-20°C or -80°C,2°C to 8°C

12352203