Histone H2A.X antibody
GTX108272
ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
TargetH2AX
Overview
- SupplierGeneTex
- Product NameHistone H2A.X antibody
- Delivery Days Customer9
- Application Supplier NoteWB: 1:500-1:20000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. IP: 1:100-1:500. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
- CertificationResearch Use Only
- ClonalityPolyclonal
- Concentration1.41 mg/ml
- ConjugateUnconjugated
- Gene ID3014
- Target nameH2AX
- Target descriptionH2A.X variant histone
- Target synonymsH2A.X, H2A/X, H2AFX, histone H2AX, H2A histone family member X, H2AX histone, histone H2A.x
- HostRabbit
- IsotypeIgG
- Protein IDP16104
- Protein NameHistone H2AX
- Scientific DescriptionHistones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene encodes a member of the histone H2A family, and generates two transcripts through the use of the conserved stem-loop termination motif, and the polyA addition motif. [provided by RefSeq]
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203
References
- Giang LH, Wu KS, Lee WC, et al. Targeting of RRM2 suppresses DNA damage response and activates apoptosis in atypical teratoid rhabdoid tumor. J Exp Clin Cancer Res. 2023,42(1):346. doi: 10.1186/s13046-023-02911-xRead this paper
- Thirunavukkarasu S, Ahmed M, Rosa BA, et al. Poly(ADP-ribose) polymerase 9 mediates early protection against Mycobacterium tuberculosis infection by regulating type I IFN production. J Clin Invest. 2023,133(12). doi: 10.1172/JCI158630Read this paper
- Liu X, Jiang Y, Takata KI, et al. CNDAC-Induced DNA Double-Strand Breaks Cause Aberrant Mitosis Prior to Cell Death. Mol Cancer Ther. 2019,18(12):2283-2295. doi: 10.1158/1535-7163.MCT-18-1380Read this paper
- Lee CY, Su GC, Huang WY, et al. Promotion of homology-directed DNA repair by polyamines. Nat Commun. 2019,10(1):65. doi: 10.1038/s41467-018-08011-1Read this paper
- Yu CY, Jerry Teng CL, Hung PS, et al. Ovatodiolide isolated from Anisomeles indica induces cell cycle G2/M arrest and apoptosis via a ROS-dependent ATM/ATR signaling pathways. Eur J Pharmacol. 2018,819:16-29. doi: 10.1016/j.ejphar.2017.09.050Read this paper
- Liu MK, Lin JJ, Chen CY, et al. Topoisomerase II Inhibitors Can Enhance Baculovirus-Mediated Gene Expression in Mammalian Cells through the DNA Damage Response. Int J Mol Sci. 2016,17(6). doi: 10.3390/ijms17060931Read this paper
- Peraldo-Neia C, Cavalloni G, Soster M, et al. Anti-cancer effect and gene modulation of ET-743 in human biliary tract carcinoma preclinical models. BMC Cancer. 2014,14:918. doi: 10.1186/1471-2407-14-918Read this paper
- Chinnam M, Wang Y, Zhang X, et al. The Thoc1 ribonucleoprotein and prostate cancer progression. J Natl Cancer Inst. 2014,106(11):pii: dju306. doi: 10.1093/jnci/dju306.Read this paper
- Yuan SS, Hou MF, Hsieh YC, et al. Role of MRE11 in cell proliferation, tumor invasion, and DNA repair in breast cancer. J Natl Cancer Inst. 2012,104(19):1485-502. doi: 10.1093/jnci/djs355Read this paper
- Chen HM, Chang FR, Hsieh YC, et al. A novel synthetic protoapigenone analogue, WYC02-9, induces DNA damage and apoptosis in DU145 prostate cancer cells through generation of reactive oxygen species. Free Radic Biol Med. 2011,50(9):1151-62. doi: 10.1016/j.freeradbiomed.2011.01.015Read this paper
Datasheet
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![IHC-P analysis of postnatal mouse (PN19) lung sections using GTX80694 Histone H2A.XS139ph (phospho Ser139) antibody [3F2]. Increased staining intensity was observed in a genetic mouse model with DNA damage in airway cells. Antigen retrieval : heat induced epitope retrieval (HIER) method with sodium citrate buffer (pH 6.0) Fixation : 4% Paraformaldehyde Dilution : 1:400](https://www.genetex.com/upload/website/prouct_img/normal/GTX80694/GTX80694_1409_IHC-P_w_23061322_374.webp)
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