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ProductsBack/Histone H2A.X antibody
Histone H2A.X antibody detects Histone H2A.X protein at nucleus by immunohistochemical analysis. Sample: Paraffin-embedded human breast carcinoma. Histone H2A.X stained by Histone H2A.X antibody (GTX108272) diluted at 1:500. Antigen Retrieval: Citrate buffer, pH 6.0, 15 min
Histone H2A.X antibody detects Histone H2A.X protein at nucleus by immunohistochemical analysis. Sample: Paraffin-embedded human breast carcinoma. Histone H2A.X stained by Histone H2A.X antibody (GTX108272) diluted at 1:500. Antigen Retrieval: Citrate buffer, pH 6.0, 15 min
Histone H2A.X antibody detects Histone H2A.X protein at nucleus by immunohistochemical analysis. Sample: Paraffin-embedded human breast carcinoma. Histone H2A.X stained by Histone H2A.X antibody (GTX108272) diluted at 1:500. Antigen Retrieval: Citrate buffer, pH 6.0, 15 min

Histone H2A.X antibody

GTX108272
GeneTex
ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman, Mouse, Rat
TargetH2AX
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Overview

  • Supplier
    GeneTex
  • Product Name
    Histone H2A.X antibody
  • Delivery Days Customer
    9
  • Application Supplier Note
    WB: 1:500-1:20000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. IP: 1:100-1:500. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    1.41 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID3014
  • Target name
    H2AX
  • Target description
    H2A.X variant histone
  • Target synonyms
    H2A.X, H2A/X, H2AFX, histone H2AX, H2A histone family member X, H2AX histone, histone H2A.x
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDP16104
  • Protein Name
    Histone H2AX
  • Scientific Description
    Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene encodes a member of the histone H2A family, and generates two transcripts through the use of the conserved stem-loop termination motif, and the polyA addition motif. [provided by RefSeq]
  • Reactivity
    Human, Mouse, Rat
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • Giang LH, Wu KS, Lee WC, et al. Targeting of RRM2 suppresses DNA damage response and activates apoptosis in atypical teratoid rhabdoid tumor. J Exp Clin Cancer Res. 2023,42(1):346. doi: 10.1186/s13046-023-02911-x
    Read this paper
  • Thirunavukkarasu S, Ahmed M, Rosa BA, et al. Poly(ADP-ribose) polymerase 9 mediates early protection against Mycobacterium tuberculosis infection by regulating type I IFN production. J Clin Invest. 2023,133(12). doi: 10.1172/JCI158630
    Read this paper
  • Liu X, Jiang Y, Takata KI, et al. CNDAC-Induced DNA Double-Strand Breaks Cause Aberrant Mitosis Prior to Cell Death. Mol Cancer Ther. 2019,18(12):2283-2295. doi: 10.1158/1535-7163.MCT-18-1380
    Read this paper
  • Lee CY, Su GC, Huang WY, et al. Promotion of homology-directed DNA repair by polyamines. Nat Commun. 2019,10(1):65. doi: 10.1038/s41467-018-08011-1
    Read this paper
  • Yu CY, Jerry Teng CL, Hung PS, et al. Ovatodiolide isolated from Anisomeles indica induces cell cycle G2/M arrest and apoptosis via a ROS-dependent ATM/ATR signaling pathways. Eur J Pharmacol. 2018,819:16-29. doi: 10.1016/j.ejphar.2017.09.050
    Read this paper
  • Liu MK, Lin JJ, Chen CY, et al. Topoisomerase II Inhibitors Can Enhance Baculovirus-Mediated Gene Expression in Mammalian Cells through the DNA Damage Response. Int J Mol Sci. 2016,17(6). doi: 10.3390/ijms17060931
    Read this paper
  • Peraldo-Neia C, Cavalloni G, Soster M, et al. Anti-cancer effect and gene modulation of ET-743 in human biliary tract carcinoma preclinical models. BMC Cancer. 2014,14:918. doi: 10.1186/1471-2407-14-918
    Read this paper
  • Chinnam M, Wang Y, Zhang X, et al. The Thoc1 ribonucleoprotein and prostate cancer progression. J Natl Cancer Inst. 2014,106(11):pii: dju306. doi: 10.1093/jnci/dju306.
    Read this paper
  • Yuan SS, Hou MF, Hsieh YC, et al. Role of MRE11 in cell proliferation, tumor invasion, and DNA repair in breast cancer. J Natl Cancer Inst. 2012,104(19):1485-502. doi: 10.1093/jnci/djs355
    Read this paper
  • Chen HM, Chang FR, Hsieh YC, et al. A novel synthetic protoapigenone analogue, WYC02-9, induces DNA damage and apoptosis in DU145 prostate cancer cells through generation of reactive oxygen species. Free Radic Biol Med. 2011,50(9):1151-62. doi: 10.1016/j.freeradbiomed.2011.01.015
    Read this paper

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