HMGA2 antibody - ChIP grade
GTX100519
ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ChIP Chromatin ImmunoPrecipitation, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman, Mouse, Rat
TargetHMGA2
Overview
- SupplierGeneTex
- Product NameHMGA2 antibody - ChIP grade
- Delivery Days Customer9
- Application Supplier NoteWB: 1:5000-1:50000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. IP: 1:100-1:500. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ChIP Chromatin ImmunoPrecipitation, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
- CertificationResearch Use Only
- ClonalityPolyclonal
- Concentration0.13 mg/ml
- ConjugateUnconjugated
- Gene ID8091
- Target nameHMGA2
- Target descriptionhigh mobility group AT-hook 2
- Target synonymsBABL; high mobility group protein HMGI-C; HMGA2/KRT121P fusion; HMGIC; HMGI-C; LIPO; SRS5; STQTL9
- HostRabbit
- IsotypeIgG
- Protein IDP52926
- Protein NameHigh mobility group protein HMGI-C
- Scientific DescriptionThis gene encodes a protein that belongs to the non-histone chromosomal high mobility group (HMG) protein family. HMG proteins function as architectural factors and are essential components of the enhancesome. This protein contains structural DNA-binding domains and may act as a transcriptional regulating factor. Identification of the deletion, amplification, and rearrangement of this gene that are associated with myxoid liposarcoma suggests a role in adipogenesis and mesenchymal differentiation. A gene knock out study of the mouse counterpart demonstrated that this gene is involved in diet-induced obesity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq]
- ReactivityHuman, Mouse, Rat
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203
References
- HMGA2 Immunoexpression is frequent in salivary gland pleomorphic adenoma: immunohistochemical and molecular analyses of PLAG1 and HMGA2 in 25 cases. Owosho AA et al., 2022, Int J Clin Exp PatholRead more
- Regulatory effect between HMGA2 and the Wnt/beta-catenin signaling pathway in the carcinogenesis of sporadic colorectal tubular adenoma. Li D et al., 2021 Dec, Oncol LettRead more
- E-cadherin Interacts With Posttranslationally-Modified AGO2 to Enhance miRISC Activity. Li JN et al., 2021, Front Cell Dev BiolRead more
- Multiple myeloma driving factor WHSC1 is a transcription target of oncogene HMGA2 that facilitates colon cancer proliferation and metastasis. Liu HH et al., 2021 Aug 27, Biochem Biophys Res CommunRead more
- HMGA1B/2 transcriptionally activated-POU1F1 facilitates gastric carcinoma metastasis via CXCL12/CXCR4 axis-mediated macrophage polarization. Tang C et al., 2021 Apr 29, Cell Death DisRead more
- Identification of HMGA2 inhibitors by AlphaScreen-based ultra-high-throughput screening assays. Su L et al., 2020 Nov 2, Sci RepRead more
- New molecular insights into the pathogenesis of lipoblastomas: clinicopathologic, immunohistochemical, and molecular analysis in pediatric cases. Lopez-Nunez O et al., 2020 Oct, Hum PatholRead more
- An HMGA2-p62-ERalpha axis regulates uterine leiomyomas proliferation. Liu B et al., 2020 Aug, FASEB JRead more
- The regulation of acetylation and stability of HMGA2 via the HBXIP-activated Akt-PCAF pathway in promotion of esophageal squamous cell carcinoma growth. Wu Y et al., 2020 May 21, Nucleic Acids ResRead more
- Dicoumarol suppresses HMGA2-mediated oncogenic capacities and inhibits cell proliferation by inducing apoptosis in colon cancer. Chen CH et al., 2020 Apr 16, Biochem Biophys Res CommunRead more