HMGA2 antibody - ChIP grade
GTX100519
ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ChIP Chromatin ImmunoPrecipitation, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
TargetHMGA2
Overview
- SupplierGeneTex
- Product NameHMGA2 antibody - ChIP grade
- Delivery Days Customer9
- Application Supplier NoteWB: 1:5000-1:50000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. IP: 1:100-1:500. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ChIP Chromatin ImmunoPrecipitation, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
- CertificationResearch Use Only
- ClonalityPolyclonal
- Concentration0.13 mg/ml
- ConjugateUnconjugated
- Gene ID8091
- Target nameHMGA2
- Target descriptionhigh mobility group AT-hook 2
- Target synonymsBABL, HMGI-C, HMGIC, LIPO, SRS5, STQTL9, high mobility group protein HMGI-C, HMGA2/KRT121P fusion
- HostRabbit
- IsotypeIgG
- Protein IDP52926
- Protein NameHigh mobility group protein HMGI-C
- Scientific DescriptionThis gene encodes a protein that belongs to the non-histone chromosomal high mobility group (HMG) protein family. HMG proteins function as architectural factors and are essential components of the enhancesome. This protein contains structural DNA-binding domains and may act as a transcriptional regulating factor. Identification of the deletion, amplification, and rearrangement of this gene that are associated with myxoid liposarcoma suggests a role in adipogenesis and mesenchymal differentiation. A gene knock out study of the mouse counterpart demonstrated that this gene is involved in diet-induced obesity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq]
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203
References
- Owosho AA, Adesina OM, Odujoko O, et al. HMGA2 Immunoexpression is frequent in salivary gland pleomorphic adenoma: immunohistochemical and molecular analyses of PLAG1 and HMGA2 in 25 cases. Int J Clin Exp Pathol. 2022,15(2):63-71.Read this paper
- Li D, Cao Y, Wang J, et al. Regulatory effect between HMGA2 and the Wnt/β-catenin signaling pathway in the carcinogenesis of sporadic colorectal tubular adenoma. Oncol Lett. 2021,22(6):849. doi: 10.3892/ol.2021.13110Read this paper
- Li JN, Sun HL, Wang MY, et al. E-cadherin Interacts With Posttranslationally-Modified AGO2 to Enhance miRISC Activity. Front Cell Dev Biol. 2021,9:671244. doi: 10.3389/fcell.2021.671244Read this paper
- Liu HH, Lee CH, Hsieh YC, et al. Multiple myeloma driving factor WHSC1 is a transcription target of oncogene HMGA2 that facilitates colon cancer proliferation and metastasis. Biochem Biophys Res Commun. 2021,567:183-189. doi: 10.1016/j.bbrc.2021.06.034Read this paper
- Tang C, Lei X, Xiong L, et al. HMGA1B/2 transcriptionally activated-POU1F1 facilitates gastric carcinoma metastasis via CXCL12/CXCR4 axis-mediated macrophage polarization. Cell Death Dis. 2021,12(5):422. doi: 10.1038/s41419-021-03703-xRead this paper
- Su L, Bryan N, Battista S, et al. Identification of HMGA2 inhibitors by AlphaScreen-based ultra-high-throughput screening assays. Sci Rep. 2020,10(1):18850. doi: 10.1038/s41598-020-75890-0Read this paper
- Lopez-Nunez O, Alaggio R, Ranganathan S, et al. New molecular insights into the pathogenesis of lipoblastomas: clinicopathologic, immunohistochemical, and molecular analysis in pediatric cases. Hum Pathol. 2020,104:30-41. doi: 10.1016/j.humpath.2020.07.016Read this paper
- Liu B, Chen G, He Q, et al. An HMGA2-p62-ERα axis regulates uterine leiomyomas proliferation. FASEB J. 2020,34(8):10966-10983. doi: 10.1096/fj.202000520RRead this paper
- Wu Y, Wang X, Xu F, et al. The regulation of acetylation and stability of HMGA2 via the HBXIP-activated Akt-PCAF pathway in promotion of esophageal squamous cell carcinoma growth. Nucleic Acids Res. 2020,48(9):4858-4876. doi: 10.1093/nar/gkaa232Read this paper
- Chen CH, Hsieh YC, Yang PM, et al. Dicoumarol suppresses HMGA2-mediated oncogenic capacities and inhibits cell proliferation by inducing apoptosis in colon cancer. Biochem Biophys Res Commun. 2020,524(4):1003-1009. doi: 10.1016/j.bbrc.2020.01.147Read this paper
Datasheet
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