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HMGA2 antibody - ChIP grade

GTX100519
GeneTex
ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ChIP Chromatin ImmunoPrecipitation, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
TargetHMGA2
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Overview

  • Supplier
    GeneTex
  • Product Name
    HMGA2 antibody - ChIP grade
  • Delivery Days Customer
    9
  • Application Supplier Note
    WB: 1:5000-1:50000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. IP: 1:100-1:500. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ChIP Chromatin ImmunoPrecipitation, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    0.13 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID8091
  • Target name
    HMGA2
  • Target description
    high mobility group AT-hook 2
  • Target synonyms
    BABL; high mobility group protein HMGI-C; HMGA2/KRT121P fusion; HMGIC; HMGI-C; LIPO; SRS5; STQTL9
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDP52926
  • Protein Name
    High mobility group protein HMGI-C
  • Scientific Description
    This gene encodes a protein that belongs to the non-histone chromosomal high mobility group (HMG) protein family. HMG proteins function as architectural factors and are essential components of the enhancesome. This protein contains structural DNA-binding domains and may act as a transcriptional regulating factor. Identification of the deletion, amplification, and rearrangement of this gene that are associated with myxoid liposarcoma suggests a role in adipogenesis and mesenchymal differentiation. A gene knock out study of the mouse counterpart demonstrated that this gene is involved in diet-induced obesity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq]
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • HMGA2 Immunoexpression is frequent in salivary gland pleomorphic adenoma: immunohistochemical and molecular analyses of PLAG1 and HMGA2 in 25 cases. Owosho AA et al., 2022, Int J Clin Exp Pathol
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  • Regulatory effect between HMGA2 and the Wnt/beta-catenin signaling pathway in the carcinogenesis of sporadic colorectal tubular adenoma. Li D et al., 2021 Dec, Oncol Lett
    Read more
  • E-cadherin Interacts With Posttranslationally-Modified AGO2 to Enhance miRISC Activity. Li JN et al., 2021, Front Cell Dev Biol
    Read more
  • Multiple myeloma driving factor WHSC1 is a transcription target of oncogene HMGA2 that facilitates colon cancer proliferation and metastasis. Liu HH et al., 2021 Aug 27, Biochem Biophys Res Commun
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  • HMGA1B/2 transcriptionally activated-POU1F1 facilitates gastric carcinoma metastasis via CXCL12/CXCR4 axis-mediated macrophage polarization. Tang C et al., 2021 Apr 29, Cell Death Dis
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  • Identification of HMGA2 inhibitors by AlphaScreen-based ultra-high-throughput screening assays. Su L et al., 2020 Nov 2, Sci Rep
    Read more
  • New molecular insights into the pathogenesis of lipoblastomas: clinicopathologic, immunohistochemical, and molecular analysis in pediatric cases. Lopez-Nunez O et al., 2020 Oct, Hum Pathol
    Read more
  • An HMGA2-p62-ERalpha axis regulates uterine leiomyomas proliferation. Liu B et al., 2020 Aug, FASEB J
    Read more
  • The regulation of acetylation and stability of HMGA2 via the HBXIP-activated Akt-PCAF pathway in promotion of esophageal squamous cell carcinoma growth. Wu Y et al., 2020 May 21, Nucleic Acids Res
    Read more
  • Dicoumarol suppresses HMGA2-mediated oncogenic capacities and inhibits cell proliferation by inducing apoptosis in colon cancer. Chen CH et al., 2020 Apr 16, Biochem Biophys Res Commun
    Read more

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