Western Blot analysis of Human hepatocellular carcinoma tissue, Hela and Jurkat cell, 293T cell and Human breast infiltRative duct tissue using HMGB1 Polyclonal Antibody at dilution of 1:200
HMGB1 Polyclonal Antibody
E-AB-15716
Product group Antibodies
Overview
- SupplierElabscience
- Product NameHMGB1 Polyclonal Antibody
- Delivery Days Customer12
- Applications SupplierELISA WB IHC
- CertificationResearch Use Only
- Concentration0.3mg/ml
- Scientific DescriptionHigh mobility group (HMG) proteins 1 and 2 are ubiquitous non-histone components of chromatin. Evidence suggests that the binding of HMG proteins to DNA induces alterations in the DNA architecture including DNA bending and unwinding of the helix. HMG proteins synergize with Oct-2, members of the NFB family, ATF-2 and c-Jun to activate transcription. Other studies indicate that phosphorylation of HMG protein is required to stimulate the transcriptional activity of the protein. Human HMG-1 and HMG-2 both contain two DNA-binding domains, termed HMG boxes. HMG proteins bind single-stranded DNA but induce conformational changes in double-stranded DNA alone.
- UNSPSC12352203





