Bio-Connect

HMGB1 antibody

GTX101277
GeneTex
ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman, Mouse, Porcine, Rat, Zebra Fish
TargetHMGB1
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Overview

  • Supplier
    GeneTex
  • Product Name
    HMGB1 antibody
  • Delivery Days Customer
    9
  • Application Supplier Note
    WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    ImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    0.43 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID3146
  • Target name
    HMGB1
  • Target description
    high mobility group box 1
  • Target synonyms
    Amphoterin; high mobility group protein B1; high-mobility group (nonhistone chromosomal) protein 1; HMG1; HMG-1; HMG3; SBP-1; Sulfoglucuronyl carbohydrate binding protein
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDP09429
  • Protein Name
    High mobility group protein B1
  • Scientific Description
    DNA binding proteins that associates with chromatin and has the ability to bend DNA. Binds preferentially single-stranded DNA. Involved in V(D)J recombination by acting as a cofactor of the RAG complex. Acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS). Heparin-binding protein that has a role in the extension of neurite-type cytoplasmic processes in developing cells.
  • Reactivity
    Human, Mouse, Porcine, Rat, Zebra Fish
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • Knockdown of HMGB1 inhibits the crosstalk between oral squamous cell carcinoma cells and tumor-associated macrophages.
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  • ATR prevents Ca(2+) overload-induced necrotic cell death through phosphorylation-mediated inactivation of PARP1 without DNA damage signaling. Li Z et al., 2021 May, FASEB J
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  • N-(2-Hydroxyphenyl)-2-Propylpentanamide (HO-AAVPA) Inhibits HDAC1 and Increases the Translocation of HMGB1 Levels in Human Cervical Cancer Cells. Sixto-Lopez Y et al., 2020 Aug 16, Int J Mol Sci
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  • Alternatively activated macrophages are associated with the alpha2AP production that occurs with the development of dermal fibrosis : The role of alternatively activated macrophages on the development of fibrosis. Kanno Y et al., 2020 Apr 10, Arthritis Res Ther
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  • RPN2 promotes metastasis of hepatocellular carcinoma cell and inhibits autophagy via STAT3 and NF-kappaB pathways. Huang L et al., 2019 Sep 3, Aging (Albany NY)
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  • N-(2-Hydroxyphenyl)-2-propylpentanamide (OH-VPA), a histone deacetylase inhibitor, induces the release of nuclear HMGB1 and modifies ROS levels in HeLa cells. Contis-Montes de Oca A et al., 2018 Sep 7, Oncotarget
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  • PARP-1 protects against colorectal tumor induction, but promotes inflammation-driven colorectal tumor progression. Doersam B et al., 2018 Apr 24, Proc Natl Acad Sci U S A
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  • HMGB1/IL-1beta complexes regulate neuroimmune responses in alcoholism. Coleman LG Jr et al., 2018 Aug, Brain Behav Immun
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  • Heparanase regulates the M1 polarization of renal macrophages and their crosstalk with renal epithelial tubular cells after ischemia/reperfusion injury. Masola V et al., 2018 Feb, FASEB J
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  • MicroRNA-200c inhibits epithelial-mesenchymal transition, invasion, and migration of lung cancer by targeting HMGB1. Liu PL et al., 2017, PLoS One
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