HMGB1 antibody
GTX101277
ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
TargetHMGB1
Overview
- SupplierGeneTex
- Product NameHMGB1 antibody
- Delivery Days Customer9
- Application Supplier NoteWB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
- CertificationResearch Use Only
- ClonalityPolyclonal
- Concentration0.43 mg/ml
- ConjugateUnconjugated
- Gene ID3146
- Target nameHMGB1
- Target descriptionhigh mobility group box 1
- Target synonymsAmphoterin; high mobility group protein B1; high-mobility group (nonhistone chromosomal) protein 1; HMG1; HMG-1; HMG3; SBP-1; Sulfoglucuronyl carbohydrate binding protein
- HostRabbit
- IsotypeIgG
- Protein IDP09429
- Protein NameHigh mobility group protein B1
- Scientific DescriptionDNA binding proteins that associates with chromatin and has the ability to bend DNA. Binds preferentially single-stranded DNA. Involved in V(D)J recombination by acting as a cofactor of the RAG complex. Acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS). Heparin-binding protein that has a role in the extension of neurite-type cytoplasmic processes in developing cells.
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203
References
- Knockdown of HMGB1 inhibits the crosstalk between oral squamous cell carcinoma cells and tumor-associated macrophages.Read more
- ATR prevents Ca(2+) overload-induced necrotic cell death through phosphorylation-mediated inactivation of PARP1 without DNA damage signaling. Li Z et al., 2021 May, FASEB JRead more
- N-(2-Hydroxyphenyl)-2-Propylpentanamide (HO-AAVPA) Inhibits HDAC1 and Increases the Translocation of HMGB1 Levels in Human Cervical Cancer Cells. Sixto-Lopez Y et al., 2020 Aug 16, Int J Mol SciRead more
- Alternatively activated macrophages are associated with the alpha2AP production that occurs with the development of dermal fibrosis : The role of alternatively activated macrophages on the development of fibrosis. Kanno Y et al., 2020 Apr 10, Arthritis Res TherRead more
- RPN2 promotes metastasis of hepatocellular carcinoma cell and inhibits autophagy via STAT3 and NF-kappaB pathways. Huang L et al., 2019 Sep 3, Aging (Albany NY)Read more
- N-(2-Hydroxyphenyl)-2-propylpentanamide (OH-VPA), a histone deacetylase inhibitor, induces the release of nuclear HMGB1 and modifies ROS levels in HeLa cells. Contis-Montes de Oca A et al., 2018 Sep 7, OncotargetRead more
- PARP-1 protects against colorectal tumor induction, but promotes inflammation-driven colorectal tumor progression. Doersam B et al., 2018 Apr 24, Proc Natl Acad Sci U S ARead more
- HMGB1/IL-1beta complexes regulate neuroimmune responses in alcoholism. Coleman LG Jr et al., 2018 Aug, Brain Behav ImmunRead more
- Heparanase regulates the M1 polarization of renal macrophages and their crosstalk with renal epithelial tubular cells after ischemia/reperfusion injury. Masola V et al., 2018 Feb, FASEB JRead more
- MicroRNA-200c inhibits epithelial-mesenchymal transition, invasion, and migration of lung cancer by targeting HMGB1. Liu PL et al., 2017, PLoS OneRead more
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