WB analysis of purified HMWK protein using GTX21005 HMW Kininogen antibody [2B5]. Lane A : WB staining Lane B : Coomassie Blue staining
WB analysis of purified HMWK protein using GTX21005 HMW Kininogen antibody [2B5]. Lane A : WB staining Lane B : Coomassie Blue staining
HMW Kininogen antibody [2B5]
GTX21005
Overview
- SupplierGeneTex
- Product NameHMW Kininogen antibody [2B5]
- Delivery Days Customer9
- Antibody SpecificityThis antibody recognizes the common heavy chain (~64kDa) of human HMWK and can neutralize the inhibitory activity of HMWK on platelet calpain.
- ApplicationsWestern Blot, ELISA
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone ID2B5
- ConjugateUnconjugated
- Gene ID3827
- Target nameKNG1
- Target descriptionkininogen 1
- Target synonymsalpha-2-thiol proteinase inhibitor; BDK; BK; bradykinin; fitzgerald factor; HAE6; high molecular weight kininogen; HMWK; kininogen-1; KNG; williams-Fitzgerald-Flaujeac factor
- HostMouse
- IsotypeIgG1
- Protein IDP01042
- Protein NameKininogen-1
- Scientific DescriptionThis gene uses alternative splicing to generate two different proteins- high molecular weight kininogen (HMWK) and low molecular weight kininogen (LMWK). HMWK is essential for blood coagulation and assembly of the kallikrein-kinin system. Also, bradykinin, a peptide causing numerous physiological effects, is released from HMWK. Bradykinin also functions as an antimicrobial peptide with antibacterial and antifungal activity. In contrast to HMWK, LMWK is not involved in blood coagulation. Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Nov 2014]
- ReactivityHuman
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203