HPK1-IN-7

Biorbyt

HPK1-IN-7 [2320462-65-3]

10

2320462-65-3

Research Use Only

C24H22N6O4

458.48

HPK1-IN-7 is a potent, orally active HPK1 (hematopoietic progenitor kinase 1, MAP4K1) inhibitor (IC50=2.6 nM) with excellent family and kinome selectivity. HPK1-IN-7 shows selectivity against IRAK4 (59 nM) and GLK (140 nM). HPK1-IN-7 shows robust efficacy against MC38 syngeneic tumor model in combination with anti-PD1.

OC[C@@H](NC1=NC(NC2=CC(C3(C)C)=C(C(O3)=O)C=C2)=NC=C1C4=NN=CO4)C5=CC=CC=C5

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