Human DR5 protein, human IgG1 Fc and His tag (active)

GeneTex

Human DR5 protein, human IgG1 Fc and His tag (active)

9

Measured by its ability to inhibit cytotoxicity assay using Jurkat human T lymphocyte. The ED50 for this effect less or equal to 5 ng/ml with TRAIL.

Functional Assay

Research Use Only

1 mg/ml

Unconjugated

TNFRSF10B

TNF receptor superfamily member 10b

CD262, DR5, KILLER, KILLER/DR5, TRAIL-R2, TRAILR2, TRICK2, TRICK2A, TRICK2B, TRICKB, ZTNFR9, tumor necrosis factor receptor superfamily member 10B, Fas-like protein, TNF-related apoptosis-inducing ligand receptor 2, apoptosis inducing protein TRICK2A/2B, apoptosis inducing receptor TRAIL-R2, cytotoxic TRAIL receptor-2, death domain containing receptor for TRAIL/Apo-2L, death receptor 5, p53-regulated DNA damage-inducible cell death receptor(killer), tumor necrosis factor receptor superfamily, member 10b, tumor necrosis factor receptor-like protein ZTNFR9

Tumor necrosis factor receptor superfamily member 10B

The protein encoded by this gene is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. Two transcript variants encoding different isoforms and one non-coding transcript have been found for this gene. [provided by RefSeq, Mar 2009]

-20°C or -80°C,2°C to 8°C

41116100

Human