HYPB/SETD2 antibody

GeneTex

HYPB/SETD2 antibody

9

WB: 1:500-1:3000. IHC-P: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

ImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Research Use Only

Polyclonal

1.22 mg/ml

Unconjugated

SETD2

SET domain containing 2, histone lysine methyltransferase

HBP231; HIF-1; HIP-1; histone-lysine N-methyltransferase SETD2; HSPC069; huntingtin interacting protein 1; huntingtin yeast partner B; huntingtin-interacting protein B; HYPB; KMT3A; LLS; lysine N-methyltransferase 3A; p231HBP; protein-lysine N-methyltransferase SETD2; SET2

Rabbit

IgG

Histone-lysine N-methyltransferase SETD2

Huntingtons disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein belonging to a class of huntingtin interacting proteins characterized by WW motifs. This protein is a histone methyltransferase that is specific for lysine-36 of histone H3, and methylation of this residue is associated with active chromatin. This protein also contains a novel transcriptional activation domain and has been found associated with hyperphosphorylated RNA polymerase II. [provided by RefSeq]

-20°C or -80°C,2°C to 8°C

12352203