IDH889

MedChem Express

IDH889 [1429179-07-6]

10

1429179-07-6

Research Use Only

99.96

C23H25FN6O2

436.48

IDH889 is an orally available, brain penetrant, allosteric and mutant specific inhibitor of isocitrate dehydrogenase 1 (IDH1) . IDH889 has potent selectivity for IDH1 R132* mutations, with IC 50 s of 0.02 microM, 0.072 microM and 1.38 microM for IDH1 R132H , IDH1 R132C and IDH1 wt , respectively. IDH889 shows potent cellular inhibition of R-2-hydroxyglutarate (2-HG) production with an IC 50 of 0.014 microM [1] .

O=C1OC[C@H](C(C)C)N1C2=NC(N[C@H](C3=NC=C(C4=CC=C(F)C(C)=C4)C=N3)C)=NC=C2

-20°C,2°C to 8°C

12352200