iFSP1 [150651-39-1]

MedChem Express

iFSP1 [150651-39-1]

10

150651-39-1

Research Use Only

99.96

C20H13N5

323.35

iFSP1 is a potent, selective and glutathione-independent inhibitor of ferroptosis suppressor protein 1 (FSP1) (AIFM2) with an EC50 of 103 nM. iFSP1 selectively induces ferroptosis in GPX4-knockout cells which overexpressed FSP1. iFSP1 is able to sensitize a variety of human cancer cell lines to the ferroptosis inducer, such as (1S,3R)-RSL3 (HY-100218A)[1].

N#CC1=C(N)N2C3=CC=CC=C3N=C2C(C#N)=C1C4=CC=C(C)C=C4

-20°C, 3 years; 4°C, 2 years (Powder)

12352200