IGF1R (phospho Tyr1131) / Insulin Receptor (phospho Tyr1146) antibody [HL3537]

GeneTex

IGF1R (phospho Tyr1131) / Insulin Receptor (phospho Tyr1146) antibody [HL3537]

9

ICC/IF: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

ImmunoFluorescence, Western Blot, ImmunoCytoChemistry

Research Use Only

Monoclonal

HL3537

1 mg/ml

Unconjugated

IGF1R

insulin like growth factor 1 receptor

CD221, IGFIR, IGFR, JTK13, insulin-like growth factor 1 receptor, IGF-I receptor

Rabbit

IgG

Insulin-like growth factor 1 receptor

This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014]

Human

-20°C or -80°C,2°C to 8°C

12352203