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IGF2R antibody [MEM-238] (Biotin)

GTX28093-02
GeneTex
ApplicationsFlow Cytometry, ImmunoPrecipitation, Western Blot
Product group Antibodies
TargetIGF2R
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Overview

  • Supplier
    GeneTex
  • Product Name
    IGF2R antibody [MEM-238] (Biotin)
  • Delivery Days Customer
    9
  • Applications
    Flow Cytometry, ImmunoPrecipitation, Western Blot
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    MEM-238
  • Concentration
    1 mg/ml
  • Conjugate
    Biotin
  • Gene ID3482
  • Target name
    IGF2R
  • Target description
    insulin like growth factor 2 receptor
  • Target synonyms
    CD222, CI-M6PR, CIMPR, M6P-R, M6P/IGF2R, MPR 300, MPR1, MPR300, MPRI, cation-independent mannose-6-phosphate receptor, 300 kDa mannose 6-phosphate receptor, CI Man-6-P receptor, IGF-II receptor, M6P/IGF2 receptor, insulin-like growth factor II receptor
  • Host
    Mouse
  • Isotype
    IgG1
  • Protein IDP11717
  • Protein Name
    Cation-independent mannose-6-phosphate receptor
  • Scientific Description
    This gene encodes a receptor for both insulin-like growth factor 2 and mannose 6-phosphate. The binding sites for each ligand are located on different segments of the protein. This receptor has various functions, including in the intracellular trafficking of lysosomal enzymes, the activation of transforming growth factor beta, and the degradation of insulin-like growth factor 2. Mutation or loss of heterozygosity of this gene has been association with risk of hepatocellular carcinoma. The orthologous mouse gene is imprinted and shows exclusive expression from the maternal allele; however, imprinting of the human gene may be polymorphic, as only a minority of individuals showed biased expression from the maternal allele (PMID:8267611). [provided by RefSeq, Nov 2015]
  • Storage Instruction
    2°C to 8°C
  • UNSPSC
    12352203

References

  • Köseoğlu HG, Bozca BC, Başsorgun Cİ, et al. The role of insulin-like growth factor in Acrochordon Etiopathology. BMC Dermatol. 2020,20(1):14. doi: 10.1186/s12895-020-00111-0
    Read this paper
  • Koeberl DD, Austin S, Case LE, et al. Adjunctive albuterol enhances the response to enzyme replacement therapy in late-onset Pompe disease. FASEB J. 2014,28(5):2171-6. doi: 10.1096/fj.13-241893
    Read this paper
  • Li S, Sun B, Nilsson MI, et al. Adjunctive β2-agonists reverse neuromuscular involvement in murine Pompe disease. FASEB J. 2013,27(1):34-44. doi: 10.1096/fj.12-207472
    Read this paper
  • Koeberl DD, Luo X, Sun B, et al. Enhanced efficacy of enzyme replacement therapy in Pompe disease through mannose-6-phosphate receptor expression in skeletal muscle. Mol Genet Metab. 2011,103(2):107-12. doi: 10.1016/j.ymgme.2011.02.006
    Read this paper

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Raji cells(black) were fixed with 4% PFA for 10min at room temperature,permeabilized with 0.1% PBST for 20 min at room temperature, and incubated in 5% BSA blocking buffer for 30 min at room temperature. Cells were then stained with IGF2R Polyclonal Antibody(bs-6670R)at 1:50 dilution in blocking buffer and incubated for 30 min at room temperature, washed twice with 2% BSA in PBS, followed by secondary antibody(blue) incubation for 40 min at room temperature. Acquisitions of 20,000 events were performed. Cells stained with primary antibody (green), and isotype control (orange).
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Figure 1. Western blot analysis of IGF2R using anti-IGF2R antibody (A00951). Electrophoresis was performed on a 5-20% SDS-PAGE gel at 70V (Stacking gel) / 90V (Resolving gel) for 2-3 hours. The sample well of each lane was loaded with 30 ug of sample under reducing conditions. Lane 1: human Hela whole cell lysates, Lane 2: human U87 whole cell lysates, Lane 3: human HepG2 whole cell lysates, Lane 4: rat heart tissue lysates, Lane 5: rat PC-12 whole cell lysates, Lane 6: mouse NIH/3T3 whole cell lysates. After electrophoresis, proteins were transferred to a nitrocellulose membrane at 150 mA for 50-90 minutes. Blocked the membrane with 5% non-fat milk/TBS for 1.5 hour at RT. The membrane was incubated with rabbit anti-IGF2R antigen affinity purified polyclonal antibody (Catalog # A00951) at 0.5 microg/mL overnight at 4°C, then washed with TBS-0.1%Tween 3 times with 5 minutes each and probed with a goat anti-rabbit IgG-HRP secondary antibody at a dilution of 1:5000 for 1.5 hour at RT. The signal is developed using an Enhanced Chemiluminescent detection (ECL) kit (Catalog # EK1002) with Tanon 5200 system. A specific band was detected for IGF2R at approximately 274 kDa. The expected band size for IGF2R is at 274 kDa.
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