Bio-Connect

IGFBP3 antibody [N2C3]

GTX100454
GeneTex
ApplicationsWestern Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman, Mouse, Rat
TargetIGFBP3
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Overview

  • Supplier
    GeneTex
  • Product Name
    IGFBP3 antibody [N2C3]
  • Delivery Days Customer
    9
  • Application Supplier Note
    WB: 1:500-1:3000. IHC-Fr: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    1.31 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID3486
  • Target name
    IGFBP3
  • Target description
    insulin like growth factor binding protein 3
  • Target synonyms
    acid stable subunit of the 140 K IGF complex; binding protein 29; binding protein 53; BP-53; growth hormone-dependent binding protein; IBP3; IBP-3; IGF-binding protein 3; IGFBP-3; insulin-like growth factor-binding protein 3
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDP17936
  • Protein Name
    Insulin-like growth factor-binding protein 3
  • Scientific Description
    This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein forms a ternary complex with insulin-like growth factor acid-labile subunit (IGFALS) and either insulin-like growth factor (IGF) I or II. In this form, it circulates in the plasma, prolonging the half-life of IGFs and altering their interaction with cell surface receptors. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq]
  • Reactivity
    Human, Mouse, Rat
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • Differential expression of hypoxia-inducible factors related to the invasiveness of epithelial ovarian cancer. Shih HJ et al., 2021 Nov 25, Sci Rep
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  • IGFBP3 inhibits angiogenesis through intracellular regulation of THBS1 expression. Shih HJ et al., 2020, Am J Cancer Res
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  • Exosomes derived from induced vascular progenitor cells promote angiogenesis in vitro and in an in vivo rat hindlimb ischemia model. Johnson TK et al., 2019 Oct 1, Am J Physiol Heart Circ Physiol
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  • Targeting insulin-like growth factor-binding protein-3 by microRNA-125b promotes tumor invasion and poor outcomes in non-small-cell lung cancer. Wang HH et al., 2017 Apr, Tumour Biol
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