IL12 Receptor beta1 antibody

GeneTex

IL12 Receptor beta1 antibody

9

The antibody shows 5% cross-reactivity with recombinant mouse IL-12 Rβ1.

WB: 0.1-0.2 microg/ml. ELISA: 0.5-1.0 microg/ml. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

Western Blot, ELISA

Research Use Only

Polyclonal

Unconjugated

IL12RB1

interleukin 12 receptor subunit beta 1

CD212; cluster of differentiation 212; IL-12 receptor beta component; IL-12 receptor subunit beta-1; IL-12R subunit beta-1; IL12RB; IL-12R-BETA1; IMD30; interleukin 12 receptor, beta 1; interleukin-12 receptor beta-1 chain; interleukin-12 receptor subunit beta-1

Goat

IgG

Interleukin-12 receptor subunit beta-1

Interleukin 12 (IL12) was identified as a factor secreted by human Epstein-Barr (EBV) transformed B cell lines. IL12, or Natural Killer Cell Stimulatory Factor (NKSF), is a 75 kDa disulfide-linked heterodimer of a 35 kDa subunit and 40 kDa subunit. IL12 is produced predominantly by monocytes and NK cells2 and induces T cells and NK cells to produce IFN gamma. Human IL12 is not active on mouse cells, but murine IL12 is active on both murine and human lymphocytes. IL12 signals through the IL12 receptor, which is composed of at least two subunits designated beta1 and beta2. Both IL12 receptor subunits are members of the hemapoietin receptor superfamily and have strong homology to the gp130 receptor. The beta1 receptor, although a low affinity binder of IL12, is not capable of transducing an IL12-mediated signal. A second subunit of the IL12 receptor was subsequently identified that when coexpressed with the beta1 subunit forms a high affinity receptor for IL12 and confers IL12 signaling.

Human

-20°C or -80°C,2°C to 8°C

12352203