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Product image
InVivoMAb anti-human CD4
BE0003-2
ApplicationsFlow Cytometry, ImmunoPrecipitation, Other Application
Product group Antibodies
ReactivityHuman
Overview
- SupplierBio X Cell
- Product NameInVivoMAb anti-human CD4
- Delivery Days Customer7
- ApplicationsFlow Cytometry, ImmunoPrecipitation, Other Application
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone IDOKT-4
- Concentration4-11 mg/ml
- HostMouse
- IsotypeIgG2b
- Scientific DescriptionThe OKT-4 monoclonal antibody reacts with the human CD4. The CD4 antigen is a 55 kDa cell surface type I membrane glycoprotein belonging to the immunoglobulin superfamily. CD4 acts as a co-receptor which in cooperation with the T cell receptor (TCR) interacts with class II MHC molecules displayed by antigen presenting cells (APC). CD4 is expressed by the majority of thymocytes, most helper T cells, a subset of NK-T cells and weakly by dendritic cells and macrophages. CD4 plays an important role in the development of T cells and is required for mature T cells to function optimally.
- ReactivityHuman
- Storage Instruction2°C to 8°C
- UNSPSC12352203
References
- Human Fcgamma-receptor IIb modulates pathogen-specific versus self-reactive antibody responses in lyme arthritis. Danzer H et al., 2020 Jul 2, ElifeRead more
- Response to Programmed Cell Death-1 Blockade in a Murine Melanoma Syngeneic Model Requires Costimulation, CD4, and CD8 T Cells. Homet Moreno B et al., 2016 Oct, Cancer Immunol ResRead more
- T cell receptor dwell times control the kinase activity of Zap70. Klammt C et al., 2015 Sep, Nat ImmunolRead more
- Characterization of human antiviral adaptive immune responses during hepatotropic virus infection in HLA-transgenic human immune system mice. Billerbeck E et al., 2013 Aug 15, J ImmunolRead more
- Antibody-mediated stripping of CD4 from lymphocyte cell surface in patients with rheumatoid arthritis. Hepburn TW et al., 2003 Jan, Rheumatology (Oxford)Read more
