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Product image
InVivoMAb anti-human CD4
BE0288
ApplicationsFlow Cytometry, ImmunoFluorescence, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, Neutralisation/Blocking
Product group Antibodies
ReactivityHuman
Overview
- SupplierBio X Cell
- Product NameInVivoMAb anti-human CD4
- Delivery Days Customer7
- ApplicationsFlow Cytometry, ImmunoFluorescence, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, Neutralisation/Blocking
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone IDRPA-T4
- Concentration4-11 mg/ml
- HostMouse
- IsotypeIgG1
- Scientific DescriptionThe RPA-T4 monoclonal antibody reacts with the human CD4. The CD4 antigen is a 55 kDa cell surface type I membrane glycoprotein belonging to the immunoglobulin superfamily. CD4 acts as a co-receptor which in cooperation with the T cell receptor (TCR) interacts with class II MHC molecules displayed by antigen presenting cells (APC). CD4 is expressed by most thymocytes and helper T cells, a subset of NK-T cells and weakly by dendritic cells and macrophages. CD4 plays an important role in the development of T cells and is required for mature T cells to function optimally. The RPA-T4 antibody is reported to bind to the D1 domain of CD4 and does not block the binding of the OKT-4 antibody. Additionally, RPA-T4 has been shown to block the binding of HIV gp120 protein to CD4 and inhibit CD4 T cell activation in vitro.
- ReactivityHuman
- Storage Instruction2°C to 8°C
- UNSPSC12352203
References
- Thioredoxin (Trx1) regulates CD4 membrane domain localization and is required for efficient CD4-dependent HIV-1 entry. Moolla N et al., 2016 Sep, Biochim Biophys ActaRead more
- CD4 blockade directly inhibits mouse and human CD4(+) T cell functions independent of Foxp3(+) Tregs. Mayer CT et al., 2013 Dec, J AutoimmunRead more
- Loss of asparagine-linked glycosylation sites in variable region 5 of human immunodeficiency virus type 1 envelope is associated with resistance to CD4 antibody ibalizumab. Toma J et al., 2011 Apr, J VirolRead more
- Biliary atresia is associated with CD4+ Th1 cell-mediated portal tract inflammation. Mack CL et al., 2004 Jul, Pediatr ResRead more
- DC-SIGN, a dendritic cell-specific HIV-1-binding protein that enhances trans-infection of T cells. Geijtenbeek TB et al., 2000 Mar 3, CellRead more
- CD40-Mediated induction of CD4 and CXCR4 on B lymphocytes correlates with restricted susceptibility to human immunodeficiency virus type 1 infection: potential role of B lymphocytes as a viral reservoir. Moir S et al., 1999 Oct, J VirolRead more
