InVivoMAb anti-human CD4

Thioredoxin (Trx1) regulates CD4 membrane domain localization and is required for efficient CD4-dependent HIV-1 entry. Moolla N et al., 2016 Sep, Biochim Biophys Acta

CD4 blockade directly inhibits mouse and human CD4(+) T cell functions independent of Foxp3(+) Tregs. Mayer CT et al., 2013 Dec, J Autoimmun

Loss of asparagine-linked glycosylation sites in variable region 5 of human immunodeficiency virus type 1 envelope is associated with resistance to CD4 antibody ibalizumab. Toma J et al., 2011 Apr, J Virol

Biliary atresia is associated with CD4+ Th1 cell-mediated portal tract inflammation. Mack CL et al., 2004 Jul, Pediatr Res

DC-SIGN, a dendritic cell-specific HIV-1-binding protein that enhances trans-infection of T cells. Geijtenbeek TB et al., 2000 Mar 3, Cell

CD40-Mediated induction of CD4 and CXCR4 on B lymphocytes correlates with restricted susceptibility to human immunodeficiency virus type 1 infection: potential role of B lymphocytes as a viral reservoir. Moir S et al., 1999 Oct, J Virol