InVivoMAb anti-mouse LFA-1alpha (CD11a)

Name: InVivoMAb anti-mouse LFA-1alpha (CD11a)
SKU: BE0005-1_B56
Availability: BackOrder

BE0005-1

ApplicationsNeutralisation/Blocking

Product group Antibodies

ReactivityMouse

Overview

Supplier
Bio X Cell
Product Name
InVivoMAb anti-mouse LFA-1alpha (CD11a)
Delivery Days Customer
7
Applications
Neutralisation/Blocking
Certification
Research Use Only
Clonality
Monoclonal
Clone ID
FD441.8
Concentration
4-11 mg/ml
Estimated Purity
>95%
Host
Rat
Isotype
IgG2b
Scientific Description
The FD441.8 monoclonal antibody reacts with mouse LFA-1α (lymphocyte function-associated antigen 1 alpha) also known as integrin alpha L chain and CD11a. LFA-1α and CD18 combine to form LFA-1, a 180 kDa glycoprotein and a member of the integrin family. LFA-1 is expressed on the surface of all leukocytes including lymphocytes, monocytes, macrophages, and granulocytes. LFA-1 plays a central role in leukocyte intercellular adhesion through interactions with its ligands, ICAM-1 (CD54), ICAM-2 (CD102), and ICAM-3 (CD50), and also functions in lymphocyte costimulatory signaling.
Reactivity
Mouse
Storage Instruction
2°C to 8°C
UNSPSC
12352203

Endogenous memory CD8 T cells directly mediate cardiac allograft rejection. Su CA et al., 2014 Mar, Am J Transplant
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Endogenous memory CD8 T cells are activated within cardiac allografts without mediating rejection. Setoguchi K et al., 2013 Sep, Am J Transplant
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Pancreatic islet xenograft survival in mice is extended by a combination of alpha-1-antitrypsin and single-dose anti-CD4/CD8 therapy. Ashkenazi E et al., 2013, PLoS One
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LFA-1 antagonism inhibits early infiltration of endogenous memory CD8 T cells into cardiac allografts and donor-reactive T cell priming. Setoguchi K et al., 2011 May, Am J Transplant
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Hapten application to the skin induces an inflammatory program directing hapten-primed effector CD8 T cell interaction with hapten-presenting endothelial cells. Kish DD et al., 2011 Feb 15, J Immunol
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Antibody-mediated B-cell depletion before adoptive immunotherapy with T cells expressing CD20-specific chimeric T-cell receptors facilitates eradication of leukemia in immunocompetent mice. James SE et al., 2009 Dec 24, Blood
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