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InVivoMAb anti-mouse LFA-1alpha (CD11a)
BE0005-1
Overview
- SupplierBio X Cell
- Product NameInVivoMAb anti-mouse LFA-1alpha (CD11a)
- Delivery Days Customer7
- ApplicationsNeutralisation/Blocking
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone IDFD441.8
- Concentration4-11 mg/ml
- HostRat
- IsotypeIgG2b
- Scientific DescriptionThe FD441.8 monoclonal antibody reacts with mouse LFA-1α (lymphocyte function-associated antigen 1 alpha) also known as integrin alpha L chain and CD11a. LFA-1α and CD18 combine to form LFA-1, a 180 kDa glycoprotein and a member of the integrin family. LFA-1 is expressed on the surface of all leukocytes including lymphocytes, monocytes, macrophages, and granulocytes. LFA-1 plays a central role in leukocyte intercellular adhesion through interactions with its ligands, ICAM-1 (CD54), ICAM-2 (CD102), and ICAM-3 (CD50), and also functions in lymphocyte costimulatory signaling.
- ReactivityMouse
- Storage Instruction2°C to 8°C
- UNSPSC12352203
References
- Endogenous memory CD8 T cells directly mediate cardiac allograft rejection. Su CA et al., 2014 Mar, Am J TransplantRead more
- Endogenous memory CD8 T cells are activated within cardiac allografts without mediating rejection. Setoguchi K et al., 2013 Sep, Am J TransplantRead more
- Pancreatic islet xenograft survival in mice is extended by a combination of alpha-1-antitrypsin and single-dose anti-CD4/CD8 therapy. Ashkenazi E et al., 2013, PLoS OneRead more
- LFA-1 antagonism inhibits early infiltration of endogenous memory CD8 T cells into cardiac allografts and donor-reactive T cell priming. Setoguchi K et al., 2011 May, Am J TransplantRead more
- Hapten application to the skin induces an inflammatory program directing hapten-primed effector CD8 T cell interaction with hapten-presenting endothelial cells. Kish DD et al., 2011 Feb 15, J ImmunolRead more
- Antibody-mediated B-cell depletion before adoptive immunotherapy with T cells expressing CD20-specific chimeric T-cell receptors facilitates eradication of leukemia in immunocompetent mice. James SE et al., 2009 Dec 24, BloodRead more
