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InVivoMAb anti-mouse LFA-1alpha (CD11a)

Research Use Only
BE0006
Bio X Cell
ApplicationsFlow Cytometry, Neutralisation/Blocking
Product group Antibodies
ReactivityMouse
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Overview

  • Supplier
    Bio X Cell
  • Product Name
    InVivoMAb anti-mouse LFA-1alpha (CD11a)
  • Delivery Days Customer
    7
  • Applications
    Flow Cytometry, Neutralisation/Blocking
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    M17/4
  • Concentration
    4-11 mg/ml
  • Host
    Rat
  • Isotype
    IgG2a
  • Scientific Description
    The M17/4 monoclonal antibody reacts with mouse LFA-1α (lymphocyte function-associated antigen 1 alpha) also known as integrin alpha L chain and CD11a. LFA-1α and CD18 combine to form LFA-1, a 180 kDa glycoprotein and a member of the integrin family. LFA-1 is expressed on the surface of all leukocytes including lymphocytes, monocytes, macrophages, and granulocytes. LFA-1 plays a central role in leukocyte intercellular adhesion through interactions with its ligands, ICAM-1 (CD54), ICAM-2 (CD102), and ICAM-3 (CD50), and also functions in lymphocyte costimulatory signaling.
  • Reactivity
    Mouse
  • Storage Instruction
    2°C to 8°C
  • UNSPSC
    12352203

References

  • Neutrophils promote Alzheimers disease-like pathology and cognitive decline via LFA-1 integrin. Zenaro E et al., 2015 Aug, Nat Med
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  • Effector lymphocyte-induced lymph node-like vasculature enables naive T-cell entry into tumours and enhanced anti-tumour immunity. Peske JD et al., 2015 May 13, Nat Commun
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  • Immunosurveillance of the liver by intravascular effector CD8(+) T cells. Guidotti LG et al., 2015 Apr 23, Cell
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  • Integrin alpha L controls the homing of regulatory T cells during CNS autoimmunity in the absence of integrin alpha 4. Glatigny S et al., 2015 Jan 16, Sci Rep
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  • Donor CD4 T cells trigger costimulation blockade-resistant donor bone marrow rejection through bystander activation requiring IL-6. Hock K et al., 2014 Sep, Am J Transplant
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  • Integrin-mediated interactions between B cells and follicular dendritic cells influence germinal center B cell fitness. Wang X et al., 2014 May 15, J Immunol
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  • Differential kinetics of antigen dependency of CD4+ and CD8+ T cells. Rabenstein H et al., 2014 Apr 15, J Immunol
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  • Secondary T cell-T cell synaptic interactions drive the differentiation of protective CD8+ T cells. Gerard A et al., 2013 Apr, Nat Immunol
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  • Intravital 2-photon imaging of leukocyte trafficking in beating heart. Li W et al., 2012 Jul, J Clin Invest
    Read more
  • Th17 lymphocytes traffic to the central nervous system independently of alpha4 integrin expression during EAE. Rothhammer V et al., 2011 Nov 21, J Exp Med
    Read more

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