InVivoMAb anti-mouse MHC Class I (H-2Kb)

Name: InVivoMAb anti-mouse MHC Class I (H-2Kb)
SKU: BE0172_B56
Availability: BackOrder

BE0172

ApplicationsFunctional Assay, Flow Cytometry, Neutralisation/Blocking, Purification/Extraction/Isolation

Product group Antibodies

ReactivityMouse

Overview

Supplier
Bio X Cell
Product Name
InVivoMAb anti-mouse MHC Class I (H-2Kb)
Delivery Days Customer
7
Applications
Functional Assay, Flow Cytometry, Neutralisation/Blocking, Purification/Extraction/Isolation
Certification
Research Use Only
Clonality
Monoclonal
Clone ID
Y-3
Concentration
4-11 mg/ml
Estimated Purity
>95%
Host
Mouse
Isotype
IgG2b
Scientific Description
The Y-3 monoclonal antibody is reported to react with the mouse H-2Kb, H-2Kk, H-2Kq, H-2Kr, H-2ksand not H-2Kd MHC class I alloantigens. MHC class I antigens are heterodimers consisting of one alpha chain (44 kDa) associated with β2 microglobulin (11.5 kDa). The antigen is expressed by all nucleated cells at varying levels. MHC Class I molecules present endogenously synthesized antigenic peptides to CD8 T cells.
Reactivity
Mouse
Storage Instruction
2°C to 8°C
UNSPSC
12352203

The Chemoattractant Receptor Ebi2 Drives Intranodal Naive CD4+ T Cell Peripheralization to Promote Effective Adaptive Immunity. Baptista AP et al., 2019 May 21, Immunity
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A Versatile Simple Capture Assay for Assessing the Structural Integrity of MHC Multimer Reagents. Reed BK et al., 2015, PLoS One
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T cells recognizing a 11mer influenza peptide complexed to H-2D(b) show promiscuity for peptide length. Zanker D et al., 2015 May-Jun, Immunol Cell Biol
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Structural and functional correlates of enhanced antiviral immunity generated by heteroclitic CD8 T cell epitopes. Trujillo JA et al., 2014 Jun 1, J Immunol
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Kinetics of antigen expression and epitope presentation during virus infection. Croft NP et al., 2013 Jan, PLoS Pathog
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CD11a regulates effector CD8 T cell differentiation and central memory development in response to infection with Listeria monocytogenes. Bose TO et al., 2013 Apr, Infect Immun
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Localization of allodeterminants on H-2Kb antigens determined with monoclonal antibodies and H-2 mutant mice. Haemmerling GJ et al., 1982 Aug, Proc Natl Acad Sci U S A
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