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ProductsBack/IRF3 antibody [5D2]
The data was published in the 2022 in Front Pharmacol. PMID: 35308231
The data was published in the 2022 in Front Pharmacol. PMID: 35308231
The data was published in the 2022 in Front Pharmacol. PMID: 35308231

IRF3 antibody [5D2]

GTX84287
GeneTex
ApplicationsWestern Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
DownloadDatasheet
Product group Antibodies
TargetIRF3
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Overview

  • Supplier
    GeneTex
  • Product Name
    IRF3 antibody [5D2] - KO/KD, Overexpression Validated
  • Delivery Days Customer
    9
  • Application Supplier Note
    WB: 1:2000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    5D2
  • Concentration
    1 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID3661
  • Target name
    IRF3
  • Target description
    interferon regulatory factor 3
  • Target synonyms
    IIAE7; interferon regulatory factor 3
  • Host
    Mouse
  • Isotype
    IgG2b
  • Scientific Description
    Mediates interferon-stimulated response element (ISRE) promoter activation. Functions as a molecular switch for antiviral activity. DsRNA generated during the course of an viral infection leads to IRF3 phosphorylation on the C-terminal serine/threonine cluster. This induces a conformational change, leading to its dimerization, nuclear localization and association with CREB binding protein (CREBBP) to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of genes under the control of ISRE. The complex binds to the IE and PRDIII regions on the IFN-alpha and IFN-beta promoters respectively. IRF-3 does not have any transcription activation domains.
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • A Polysaccharide From Eupolyphaga sinensis Walker With Anti-HBV Activities In Vitro and In Vivo. Zhang X et al., 2022, Front Pharmacol
    Read more

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