The data was published in the 2022 in Front Pharmacol. PMID: 35308231
![IHC-P analysis of breast adenocarcinoma tissue using GTX84287 IRF3 antibody [5D2]. Antigen retrieval : Heat-induced epitope retrieval by 10mM citrate buffer, pH6.0, 100oC for 10min. Dilution : 1:50](https://www.genetex.com/upload/website/prouct_img/normal/GTX84287/GTX84287_2555_IHC-P_w_23061420_863.webp "IHC-P analysis of breast adenocarcinoma tissue using GTX84287 IRF3 antibody [5D2]. Antigen retrieval : Heat-induced epitope retrieval by 10mM citrate buffer, pH6.0, 100oC for 10min. Dilution : 1:50")
![IHC-P analysis of colon adenocarcinoma tissue using GTX84287 IRF3 antibody [5D2]. Antigen retrieval : Heat-induced epitope retrieval by 10mM citrate buffer, pH6.0, 100oC for 10min. Dilution : 1:50](https://www.genetex.com/upload/website/prouct_img/normal/GTX84287/GTX84287_2556_IHC-P_w_23061420_433.webp "IHC-P analysis of colon adenocarcinoma tissue using GTX84287 IRF3 antibody [5D2]. Antigen retrieval : Heat-induced epitope retrieval by 10mM citrate buffer, pH6.0, 100oC for 10min. Dilution : 1:50")
![IHC-P analysis of human ovary adenocarcinoma tissue using GTX84287 IRF3 antibody [5D2]. Antigen retrieval : Heat-induced epitope retrieval by 10mM citrate buffer, pH6.0, 100oC for 10min. Dilution : 1:50](https://www.genetex.com/upload/website/prouct_img/normal/GTX84287/GTX84287_2557_IHC-P_w_23061420_427.webp "IHC-P analysis of human ovary adenocarcinoma tissue using GTX84287 IRF3 antibody [5D2]. Antigen retrieval : Heat-induced epitope retrieval by 10mM citrate buffer, pH6.0, 100oC for 10min. Dilution : 1:50")
![IHC-P analysis of breast tissue using GTX84287 IRF3 antibody [5D2]. Antigen retrieval : Heat-induced epitope retrieval by 10mM citrate buffer, pH6.0, 100oC for 10min. Dilution : 1:50](https://www.genetex.com/upload/website/prouct_img/normal/GTX84287/GTX84287_2558_IHC-P_w_23061420_399.webp "IHC-P analysis of breast tissue using GTX84287 IRF3 antibody [5D2]. Antigen retrieval : Heat-induced epitope retrieval by 10mM citrate buffer, pH6.0, 100oC for 10min. Dilution : 1:50")
![IHC-P analysis of bladder carcinoma tissue using GTX84287 IRF3 antibody [5D2]. Antigen retrieval : Heat-induced epitope retrieval by 10mM citrate buffer, pH6.0, 100oC for 10min. Dilution : 1:50](https://www.genetex.com/upload/website/prouct_img/normal/GTX84287/GTX84287_2559_IHC-P_w_23061420_804.webp "IHC-P analysis of bladder carcinoma tissue using GTX84287 IRF3 antibody [5D2]. Antigen retrieval : Heat-induced epitope retrieval by 10mM citrate buffer, pH6.0, 100oC for 10min. Dilution : 1:50")
![IHC-P analysis of kidney carcinoma tissue using GTX84287 IRF3 antibody [5D2]. Antigen retrieval : Heat-induced epitope retrieval by 10mM citrate buffer, pH6.0, 100oC for 10min. Dilution : 1:50](https://www.genetex.com/upload/website/prouct_img/normal/GTX84287/GTX84287_2560_IHC-P_w_23061420_137.webp "IHC-P analysis of kidney carcinoma tissue using GTX84287 IRF3 antibody [5D2]. Antigen retrieval : Heat-induced epitope retrieval by 10mM citrate buffer, pH6.0, 100oC for 10min. Dilution : 1:50")
![IHC-P analysis of pancreas carcinoma tissue using GTX84287 IRF3 antibody [5D2]. Antigen retrieval : Heat-induced epitope retrieval by 10mM citrate buffer, pH6.0, 100oC for 10min. Dilution : 1:50](https://www.genetex.com/upload/website/prouct_img/normal/GTX84287/GTX84287_2561_IHC-P_w_23061420_489.webp "IHC-P analysis of pancreas carcinoma tissue using GTX84287 IRF3 antibody [5D2]. Antigen retrieval : Heat-induced epitope retrieval by 10mM citrate buffer, pH6.0, 100oC for 10min. Dilution : 1:50")
![IHC-P analysis of prostate carcinoma tissue using GTX84287 IRF3 antibody [5D2]. Antigen retrieval : Heat-induced epitope retrieval by 10mM citrate buffer, pH6.0, 100oC for 10min. Dilution : 1:50](https://www.genetex.com/upload/website/prouct_img/normal/GTX84287/GTX84287_2562_IHC-P_w_23061420_871.webp "IHC-P analysis of prostate carcinoma tissue using GTX84287 IRF3 antibody [5D2]. Antigen retrieval : Heat-induced epitope retrieval by 10mM citrate buffer, pH6.0, 100oC for 10min. Dilution : 1:50")
![IHC-P analysis of thyroid carcinoma tissue using GTX84287 IRF3 antibody [5D2]. Antigen retrieval : Heat-induced epitope retrieval by 10mM citrate buffer, pH6.0, 100oC for 10min. Dilution : 1:50](https://www.genetex.com/upload/website/prouct_img/normal/GTX84287/GTX84287_2563_IHC-P_w_23061420_681.webp "IHC-P analysis of thyroid carcinoma tissue using GTX84287 IRF3 antibody [5D2]. Antigen retrieval : Heat-induced epitope retrieval by 10mM citrate buffer, pH6.0, 100oC for 10min. Dilution : 1:50")
The data was published in the 2022 in Front Pharmacol. PMID: 35308231
IRF3 antibody [5D2]
GTX84287
ApplicationsWestern Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman, Monkey
TargetIRF3
Overview
- SupplierGeneTex
- Product NameIRF3 antibody [5D2] - KO/KD, Overexpression Validated
- Delivery Days Customer9
- Application Supplier NoteWB: 1:2000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- ApplicationsWestern Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone ID5D2
- Concentration1 mg/ml
- ConjugateUnconjugated
- Gene ID3661
- Target nameIRF3
- Target descriptioninterferon regulatory factor 3
- Target synonymsIIAE7; interferon regulatory factor 3
- HostMouse
- IsotypeIgG2b
- Scientific DescriptionMediates interferon-stimulated response element (ISRE) promoter activation. Functions as a molecular switch for antiviral activity. DsRNA generated during the course of an viral infection leads to IRF3 phosphorylation on the C-terminal serine/threonine cluster. This induces a conformational change, leading to its dimerization, nuclear localization and association with CREB binding protein (CREBBP) to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of genes under the control of ISRE. The complex binds to the IE and PRDIII regions on the IFN-alpha and IFN-beta promoters respectively. IRF-3 does not have any transcription activation domains.
- ReactivityHuman, Monkey
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203
References
- A Polysaccharide From Eupolyphaga sinensis Walker With Anti-HBV Activities In Vitro and In Vivo. Zhang X et al., 2022, Front PharmacolRead more