JNJ-28583113

AbMole BioScience

JNJ-28583113

9

2765255-93-2

Research Use Only

C19H21F3N2O2

366.38

JNJ-28583113 is a brain-permeable TRPM2 antagonist and blocks phosphorylation of GSK3alfa and bèta subunits by inhibiting TRPM2. In addition, JNJ-28583113 inhibits cytokine release from microglia in response to pro-inflammatory stimuli. It has the function of protecting cells from oxidative stress-induced cell death.

12352200