JNJ-28583113

Biorbyt

JNJ-28583113

10

Research Use Only

98.00%

C19H21F3N2O2

366.38

JNJ-28583113, a TRPM2 antagonist with brain permeability, inhibits the phosphorylation of GSK3alpha and beta subunits, thereby protecting cells from oxidative stress-induced cell death. Additionally, it suppresses cytokine release in response to pro-inflammatory stimuli in microglia [1].

O=C(OCC)CN1N=C(C=2C=CC(=CC2)C(F)(F)F)C3=C1CCCCC3

-20°C

12352200