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ProductsBack/(+)-JQ1 [1268524-70-4]
Chemical Structure
Chemical Structure
Chemical Structure

(+)-JQ1 [1268524-70-4]

SYN-3004
SYNkinase
CAS Number1268524-70-4
Product group Chemicals
Estimated Purity>95%
Molecular Weight457
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Overview

  • Supplier
    SYNkinase
  • Product Name
    (+)-JQ1 [1268524-70-4]
  • Delivery Days Customer
    10
  • CAS Number
    1268524-70-4
  • Certification
    Research Use Only
  • Estimated Purity
    >95%
  • Molecular Formula
    C23H25ClN4O2S
  • Molecular Weight
    457
  • Scientific Description
    (+)-JQ1 is a potent, high affinity, selective BET bromodomain inhibitor (IC(50) values of 17.7, 32.6, 76.9 and 12942nM respectively for BRD2 (N-terminal (N)), BRD4 (C-terminal (C)), BRD4 (N) and CREBBP, respectively. In binding assays, (+)-JQ1 binds competitive with acetyl lysine to BRD4 bromodomain 1 (Kd=50nM) and and BRD4 bromodomain 2 (Kd=90 nM). May be a useful chemical probe to investigate the role of BET bromodomains in the transcriptional regulation of oncogenesis. (+)-JQ1 exhibited strong dose- and time-dependent inhibition of BRDT, a bromodomain-containing protein highly enriched in testis. BRDT is involved in chromatin remodeling and is essential for healthy sperm development. (+)-JQ1 appears to block that function and causes a decrease in sperm viability, being examined as a potential male contraceptive. Inhibitor of inflammation and bone destruction. - Chemical. CAS: 1268524-70-4. Formula: C23H25ClN4O2S. MW: 457. (+)-JQ1 is a potent, high affinity, selective BET bromodomain inhibitor (IC(50) values of 17.7, 32.6, 76.9 and 12942nM respectively for BRD2 (N-terminal (N)), BRD4 (C-terminal (C)), BRD4 (N) and CREBBP, respectively. In binding assays, (+)-JQ1 binds competitive with acetyl lysine to BRD4 bromodomain 1 (Kd=50nM) and and BRD4 bromodomain 2 (Kd=90 nM). May be a useful chemical probe to investigate the role of BET bromodomains in the transcriptional regulation of oncogenesis. (+)-JQ1 exhibited strong dose- and time-dependent inhibition of BRDT, a bromodomain-containing protein highly enriched in testis. BRDT is involved in chromatin remodeling and is essential for healthy sperm development. (+)-JQ1 appears to block that function and causes a decrease in sperm viability, being examined as a potential male contraceptive. Inhibitor of inflammation and bone destruction.
  • Storage Instruction
    2°C to 8°C
  • UNSPSC
    51202000