ProductsBack/KDM3B Polyclonal Antibody

Immunohistochemistry of paraffin-embedded Human lung cancer tissue using KDM3B Polyclonal Antibody at dilution 1:50

KDM3B Polyclonal Antibody

E-AB-15146

Product group Antibodies

Overview

Supplier
Elabscience
Product Name
KDM3B Polyclonal Antibody
Delivery Days Customer
12
Applications Supplier
ELISA IHC
Certification
Research Use Only
Concentration
0.3mg/ml
Scientific Description
JMJD1B (jumonji domain containing 1B), also known as KDM3B, 5qNCA (5q Nuclear Co-Activator) or C5orf7, is a member of the JHDM2 histone demethylase family of proteins. Expressed in a wide variety of tissues, JMJD1B localizes to the nucleus and contains one JMJC domain and a C-terminal zinc finger motif. JMJD1B functions as a histone demethylase and, using iron as a cofactor, demethylates lysine-9 of Histone H3. This suggests that JMJD1B plays a central role in the histone code. The gene encoding human JMJD1B is located within the 5q region of the genome that is often deleted in myeloid leukemias and myelodysplasias. This implies that JMJD1B may function as a tumor suppressor of myeloid leukemia. Eptopic expression of JMJD1B exhibits growth suppressive activities, further supporting a role for JMJD1B in tumor suppression.
UNSPSC
12352203

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