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ProductsBack/KDM6A antibody [N2C1], Internal

KDM6A antibody [N2C1], Internal

GTX121246
GeneTex
ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ChIP Chromatin ImmunoPrecipitation, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
DownloadDatasheet
Product group Antibodies
TargetKDM6A
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Overview

  • Supplier
    GeneTex
  • Product Name
    KDM6A antibody [N2C1], Internal
  • Delivery Days Customer
    9
  • Application Supplier Note
    WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. IP: 1:100-1:500. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ChIP Chromatin ImmunoPrecipitation, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    0.68 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID7403
  • Target name
    KDM6A
  • Target description
    lysine demethylase 6A
  • Target synonyms
    [histone H3]-trimethyl-L-lysine(27) demethylase 6A; bA386N14.2; bA386N14.2 (ubiquitously transcribed X chromosome tetratricopeptide repeat protein (UTX)); histone demethylase UTX; KABUK2; lysine (K)-specific demethylase 6A; lysine-specific demethylase 6A; ubiquitously transcribed tetratricopeptide repeat protein X-linked; ubiquitously-transcribed TPR gene on the X chromosome; UTX
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDO15550
  • Protein Name
    Lysine-specific demethylase 6A
  • Scientific Description
    This gene is located on the X chromosome and is the corresponding locus to a Y-linked gene which encodes a tetratricopeptide repeat (TPR) protein. The encoded protein of this gene contains a JmjC-domain and catalyzes the demethylation of tri/dimethylated histone H3. [provided by RefSeq]
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • CUL4B-DDB1-COP1-mediated UTX downregulation promotes colorectal cancer progression.
    Read more
  • Catalytic domain-dependent and -independent transcriptional activities of the tumour suppressor histone H3K27 demethylase UTX/KDM6A in specific cancer types.
    Read more
  • A KDM6 inhibitor potently induces ATF4 and its target gene expression through HRI activation and by UTX inhibition. Kitajima S et al., 2021 Feb 25, Sci Rep
    Read more
  • A second X chromosome contributes to resilience in a mouse model of Alzheimers disease. Davis EJ et al., 2020 Aug 26, Sci Transl Med
    Read more
  • UTX Regulates Human Neural Differentiation and Dendritic Morphology by Resolving Bivalent Promoters. Tang QY et al., 2020 Aug 11, Stem Cell Reports
    Read more
  • Histone methylation and demethylation are implicated in the transient and sustained activation of the interleukin-1beta gene in murine macrophages. Imuta H et al., 2020 Dec, Heart Vessels
    Read more
  • Cancer Stem Cell-Inducing Media Activates Senescence Reprogramming in Fibroblasts. Perrigue PM et al., 2020 Jun 30, Cancers (Basel)
    Read more
  • Cancer-derived UTX TPR mutations G137V and D336G impair interaction with MLL3/4 complexes and affect UTX subcellular localization. Kato H et al., 2020 Apr, Oncogene
    Read more
  • UTX-mediated enhancer and chromatin remodeling suppresses myeloid leukemogenesis through noncatalytic inverse regulation of ETS and GATA programs. Gozdecka M et al., 2018 Jun, Nat Genet
    Read more
  • Lkb1 inactivation drives lung cancer lineage switching governed by Polycomb Repressive Complex 2. Zhang H et al., 2017 Apr 7, Nat Commun
    Read more

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Figure 1. Western blot analysis of UTX/KDM6A using anti-UTX/KDM6A antibody (A01286-2). Electrophoresis was performed on a 5-20% SDS-PAGE gel at 70V (Stacking gel) / 90V (Resolving gel) for 2-3 hours. The sample well of each lane was loaded with 30 ug of sample under reducing conditions. Lane 1: human MCF-7 whole cell lysates, Lane 2: human HEK293 whole cell lysates. After electrophoresis, proteins were transferred to a nitrocellulose membrane at 150 mA for 50-90 minutes. Blocked the membrane with 5% non-fat milk/TBS for 1.5 hour at RT. The membrane was incubated with rabbit anti-UTX/KDM6A antigen affinity purified polyclonal antibody (Catalog # A01286-2) at 0.5 microg/mL overnight at 4°C, then washed with TBS-0.1%Tween 3 times with 5 minutes each and probed with a goat anti-rabbit IgG-HRP secondary antibody at a dilution of 1:5000 for 1.5 hour at RT. The signal is developed using an Enhanced Chemiluminescent detection (ECL) kit (Catalog # EK1002) with Tanon 5200 system. A specific band was detected for UTX/KDM6A at approximately 154 kDa. The expected band size for UTX/KDM6A is at 154 kDa.
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