KDM6A antibody [N2C1], Internal
GTX121246
ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ChIP Chromatin ImmunoPrecipitation, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
TargetKDM6A
Overview
- SupplierGeneTex
- Product NameKDM6A antibody [N2C1], Internal
- Delivery Days Customer9
- Application Supplier NoteWB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. IP: 1:100-1:500. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ChIP Chromatin ImmunoPrecipitation, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
- CertificationResearch Use Only
- ClonalityPolyclonal
- Concentration0.68 mg/ml
- ConjugateUnconjugated
- Gene ID7403
- Target nameKDM6A
- Target descriptionlysine demethylase 6A
- Target synonymsKABUK2, UTX, bA386N14.2, lysine-specific demethylase 6A, [histone H3]-trimethyl-L-lysine(27) demethylase 6A, bA386N14.2 (ubiquitously transcribed X chromosome tetratricopeptide repeat protein (UTX)), histone demethylase UTX, lysine (K)-specific demethylase 6A, ubiquitously transcribed tetratricopeptide repeat protein X-linked, ubiquitously-transcribed TPR gene on the X chromosome
- HostRabbit
- IsotypeIgG
- Protein IDO15550
- Protein NameLysine-specific demethylase 6A
- Scientific DescriptionThis gene is located on the X chromosome and is the corresponding locus to a Y-linked gene which encodes a tetratricopeptide repeat (TPR) protein. The encoded protein of this gene contains a JmjC-domain and catalyzes the demethylation of tri/dimethylated histone H3. [provided by RefSeq]
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203
References
- Luo D, Chen M, Li Q, et al. CUL4B-DDB1-COP1-mediated UTX downregulation promotes colorectal cancer progression. Exp Hematol Oncol. 2023,12(1):77. doi: 10.1186/s40164-023-00440-zRead this paper
- Sun W, Lee KL, Poellinger L, et al. Catalytic domain-dependent and -independent transcriptional activities of the tumour suppressor histone H3K27 demethylase UTX/KDM6A in specific cancer types. Epigenetics. 2023,18(1):2222245. doi: 10.1080/15592294.2023.2222245Read this paper
- Kitajima S, Sun W, Lee KL, et al. A KDM6 inhibitor potently induces ATF4 and its target gene expression through HRI activation and by UTX inhibition. Sci Rep. 2021,11(1):4538. doi: 10.1038/s41598-021-83857-yRead this paper
- Davis EJ, Broestl L, Abdulai-Saiku S, et al. A second X chromosome contributes to resilience in a mouse model of Alzheimer's disease. Sci Transl Med. 2020,12(558). doi: 10.1126/scitranslmed.aaz5677Read this paper
- Tang QY, Zhang SF, Dai SK, et al. UTX Regulates Human Neural Differentiation and Dendritic Morphology by Resolving Bivalent Promoters. Stem Cell Reports. 2020,15(2):439-453. doi: 10.1016/j.stemcr.2020.06.015Read this paper
- Imuta H, Fujita D, Oba S, et al. Histone methylation and demethylation are implicated in the transient and sustained activation of the interleukin-1β gene in murine macrophages. Heart Vessels. 2020,35(12):1746-1754. doi: 10.1007/s00380-020-01670-5Read this paper
- Perrigue PM, Rakoczy M, Pawlicka KP, et al. Cancer Stem Cell-Inducing Media Activates Senescence Reprogramming in Fibroblasts. Cancers (Basel). 2020,12(7). doi: 10.3390/cancers12071745Read this paper
- Kato H, Asamitsu K, Sun W, et al. Cancer-derived UTX TPR mutations G137V and D336G impair interaction with MLL3/4 complexes and affect UTX subcellular localization. Oncogene. 2020,39(16):3322-3335. doi: 10.1038/s41388-020-1218-3Read this paper
- Gozdecka M, Meduri E, Mazan M, et al. UTX-mediated enhancer and chromatin remodeling suppresses myeloid leukemogenesis through noncatalytic inverse regulation of ETS and GATA programs. Nat Genet. 2018,50(6):883-894. doi: 10.1038/s41588-018-0114-zRead this paper
- Zhang H, Fillmore Brainson C, Koyama S, et al. Lkb1 inactivation drives lung cancer lineage switching governed by Polycomb Repressive Complex 2. Nat Commun. 2017,8:14922. doi: 10.1038/ncomms14922Read this paper
Datasheet
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