KEAP1 Antibody, FITC conjugated
CSB-PA012147LC01HU
ReactivityHuman
Product group Antibodies
TargetKEAP1
Overview
- SupplierCusabio
- Product NameKEAP1 Antibody, FITC conjugated
- Delivery Days Customer20
- CertificationResearch Use Only
- ClonalityPolyclonal
- ConjugateFITC
- Gene ID9817
- Target nameKEAP1
- Target descriptionkelch like ECH associated protein 1
- Target synonymscytosolic inhibitor of Nrf2; INrf2; KEAP1 delta C; kelch-like ECH-associated protein 1; kelch-like family member 19; kelch-like protein 19; KLHL19
- HostRabbit
- IsotypeIgG
- Protein IDQ14145
- Protein NameKelch-like ECH-associated protein 1
- Scientific DescriptionActs as a substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1 and targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. Retains NFE2L2/NRF2 and may also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome.
- ReactivityHuman
- Storage Instruction-20°C or -80°C
- UNSPSC12352203