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WB analysis of various sample lysates using GTX54329 KEAP1 antibody. Dilution : 1:1000 Loading : 25microg per lane

KEAP1 antibody

GTX54329

ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Product group Antibodies

TargetKEAP1

Overview

Supplier
GeneTex
Product Name
KEAP1 antibody
Delivery Days Customer
7
Application Supplier Note
WB: 1:500 - 1:2000. ICC/IF: 1:50 - 1:200. IHC-P: 1:50 - 1:200. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Applications
ImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Certification
Research Use Only
Clonality
Polyclonal
Conjugate
Unconjugated
Gene ID9817
Target name
KEAP1
Target description
kelch like ECH associated protein 1
Target synonyms
INrf2, KLHL19, kelch-like ECH-associated protein 1, KEAP1 delta C, cytosolic inhibitor of Nrf2, kelch-like family member 19, kelch-like protein 19
Host
Rabbit
Isotype
IgG
Protein IDQ14145
Protein Name
Kelch-like ECH-associated protein 1
Scientific Description
This gene encodes a protein containing KELCH-1 like domains, as well as a BTB/POZ domain. Kelch-like ECH-associated protein 1 interacts with NF-E2-related factor 2 in a redox-sensitive manner and the dissociation of the proteins in the cytoplasm is followed by transportation of NF-E2-related factor 2 to the nucleus. This interaction results in the expression of the catalytic subunit of gamma-glutamylcysteine synthetase. Two alternatively spliced transcript variants encoding the same isoform have been found for this gene. [provided by RefSeq, Jul 2008]
Storage Instruction
-20°C or -80°C,2°C to 8°C
UNSPSC
12352203

Wu CT, Deng JS, Huang WC, et al. Salvianolic Acid C against Acetaminophen-Induced Acute Liver Injury by Attenuating Inflammation, Oxidative Stress, and Apoptosis through Inhibition of the Keap1/Nrf2/HO-1 Signaling. Oxid Med Cell Longev. 2019,2019:9056845. doi: 10.1155/2019/9056845
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Lee J, Song K, Huh E, et al. Neuroprotection against 6-OHDA toxicity in PC12 cells and mice through the Nrf2 pathway by a sesquiterpenoid from Tussilago farfara. Redox Biol. 2018,18:6-15. doi: 10.1016/j.redox.2018.05.015
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Tapia E, García-Arroyo F, Silverio O, et al. Mycophenolate mofetil and curcumin provide comparable therapeutic benefit in experimental chronic kidney disease: role of Nrf2-Keap1 and renal dopamine pathways. Free Radic Res. 2016,50(7):781-92. doi: 10.1080/10715762.2016.1174776
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Lee JC, Tseng CK, Young KC, et al. Andrographolide exerts anti-hepatitis C virus activity by up-regulating haeme oxygenase-1 via the p38 MAPK/Nrf2 pathway in human hepatoma cells. Br J Pharmacol. 2014,171(1):237-52. doi: 10.1111/bph.12440
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