KEAP1 Antibody, HRP conjugated

Cusabio

KEAP1 Antibody, HRP conjugated

20

ELISA

Research Use Only

Polyclonal

HRP

KEAP1

kelch like ECH associated protein 1

cytosolic inhibitor of Nrf2; INrf2; KEAP1 delta C; kelch-like ECH-associated protein 1; kelch-like family member 19; kelch-like protein 19; KLHL19

Rabbit

IgG

Kelch-like ECH-associated protein 1

Acts as a substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1 and targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. Retains NFE2L2/NRF2 and may also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome.

Human

-20°C or -80°C

12352203