KRIT1 antibody [C1C3]

GeneTex

KRIT1 antibody [C1C3]

9

WB: 1:500-1:3000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

Electron Microscopy, Western Blot

Research Use Only

Polyclonal

0.74 mg/ml

Unconjugated

KRIT1

KRIT1 ankyrin repeat containing

CAM, CCM1, krev interaction trapped protein 1, ankyrin repeat-containing protein Krit1, cerebral cavernous malformations 1 protein, krev interaction trapped 1

Rabbit

IgG

Krev interaction trapped protein 1

This gene encodes a protein containing four ankyrin repeats, a band 4.1/ezrin/radixin/moesin (FERM) domain, and multiple NPXY sequences. The encoded protein is localized in the nucleus and cytoplasm. It binds to integrin cytoplasmic domain-associated protein-1 alpha (ICAP1alpha), and plays a critical role in beta1-integrin-mediated cell proliferation. It associates with junction proteins and RAS-related protein 1A (Rap1A), which requires the encoded protein for maintaining the integrity of endothelial junctions. It is also a microtubule-associated protein and may play a role in microtubule targeting. Mutations in this gene result in cerebral cavernous malformations. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq]

Human

-20°C or -80°C,2°C to 8°C

12352203