L-2-Hydroxyglutaric acid

Biorbyt

L-2-Hydroxyglutaric acid

10

13095-48-2

Research Use Only

98.00%

C5H8O5

148.11

L-2-Hydroxyglutaric acid (L-2-HG) is a compartmentalized metabolite and a substrate for L-2-hydroxyglutarate dehydrogenase (L2HGDH). It inhibits histone demethylases and increases the expression of ATF4 and its target genes by activating the mTOR pathway. L-2-Hydroxyglutaric acid mediates the mTOR-ATF4 signaling pathway and can be used in biosensor research.

[C@H](CCC(O)=O)(C(O)=O)O

-20°C

12352200