L-2-Hydroxyglutaric acid [13095-48-2]
T13749
CAS Number13095-48-2
Product group Chemicals
Molecular Weight148.11
Overview
- SupplierTargetMol Chemicals
- Product NameL-2-Hydroxyglutaric acid [13095-48-2]
- Delivery Days Customer44
- CAS Number13095-48-2
- CertificationResearch Use Only
- Chemical NameL-2-Hydroxyglutaric acid
- Molecular FormulaC5H8O5
- Molecular Weight148.11
- Scientific DescriptionL-2-Hydroxyglutaric acid, an epigenetic modifier and potential oncometabolite in renal cancer, impedes mitochondrial creatine kinase (Mi-CK) activity, exhibiting Km and Ki values of 2.52 mM and 11.13 mM, respectively. Additionally, it obstructs histone demethylases, thereby encouraging histone methylation.
- Shelf life instruction3 years
- SMILES[C@H](CCC(O)=O)(C(O)=O)O
- Storage Instruction-20°C
- UNSPSC12352200
References
- Shim EH, Livi CB, Rakheja D, et al. L-2-Hydroxyglutarate: an epigenetic modifier and putative oncometabolite in renal cancer. Cancer Discov. 2014,4(11):1290-8. doi: 10.1158/2159-8290.CD-13-0696Read this paper
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