LC-2

MedChem Express

LC-2 [2502156-03-6]

10

2502156-03-6

Research Use Only

98.16

C59H71ClFN11O7S

1132.78

LC-2 is a potent and first-in-class von Hippel-Lindau -based PROTAC capable of degrading endogenous KRAS G12C , with DC 50 s between 0.25 and 0.76 microM [1] . LC-2 covalently binds KRAS G12C with a MRTX849 warhead and recruits the E3 ligase VHL, inducing rapid and sustained KRAS G12C degradation leading to suppression of MAPK signaling in both homozygous and heterozygous KRAS G12C cell lines [2] .

O=C(NCC1=CC=C(C=C1)C2=C(N=CS2)C)[C@H]3N(C[C@@H](C3)O)C([C@H](C(C)(C)C)NC(CCOCCCN4[C@@H](CCC4)COC5=NC(N6C[C@@H](N(CC6)C(C(F)=C)=O)CC#N)=C7C(CN(CC7)C8=C9C(Cl)=CC=CC9=CC=C8)=N5)=O)=O

-20°C,2°C to 8°C

12352200