![LC-2 [2502156-03-6] LC-2 [2502156-03-6]](https://www.targetmol.com/group3/M00/37/D8/CgoaEWayUsWEb4OKAAAAANwT8vQ421.png)
LC-2 [2502156-03-6]
T36256
Overview
- SupplierTargetMol Chemicals
- Product NameLC-2 [2502156-03-6]
- Delivery Days Customer9
- CAS Number2502156-03-6
- Category SupplierChemical
- CertificationResearch Use Only
- Chemical NameLC-2
- Estimated Purity98%
- Molecular FormulaC59H71ClFN11O7S
- Molecular Weight1132.78
- Scientific DescriptionLC-2 (PROTAC KRASG12C Degrader-LC-2) is a novel von Hippel-Lindau-based PROTAC degrader of endogenous KRAS G12C with a DC50 between 0.25 and 0.76 microM.LC-2 is a PROTAC that covalently binds KRAS G12C with MRTX849 and recruits the E3 ligase, VH, to induce a rapid and sustained degradation of KRAS G12C. LC-2 inhibits MAPK signaling in pure and heterozygous KRAS G12C cell lines.
- Shelf life instruction3 years
- SMILESCc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCOCCCN2CCC[C@H]2COc2nc3CN(CCc3c(n2)N2CCN([C@@H](CC#N)C2)C(=O)C(F)=C)c2cccc3cccc(Cl)c23)C(C)(C)C)cc1
- Storage Instruction-20°C
- UNSPSC12352200