LC-2 [2502156-03-6]

BPS Bioscience

LC-2

7

2502156-03-6

Research Use Only

C59H71ClFN11O7S

1132.8 Da

LC-2 is a von Hippel-Lindau-based PROTAC which can degrade endogenous KRAS G12C. It covalently binds KRAS G12C with a MARTX849 warhead and recruits the E3 ligase VHL which degrades the KRAS G12C and suppresses MAPK signaling in homozygous and heterozygous KRAS G12C cell lines.

-20°C

12352200