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WB analysis of arsenic trioxide treated U87-MG cell lysate using GTX82986 LC3B antibody.

LC3B antibody

GTX82986

ApplicationsElectron Microscopy, ImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, ImmunoHistoChemistry Paraffin

Product group Antibodies

ReactivityBovine, Canine, Human, Mouse, Porcine, Primate, Rat, Zebra Fish

TargetMAP1LC3B

Overview

Supplier
GeneTex
Product Name
LC3B antibody
Delivery Days Customer
9
Application Supplier Note
WB: 1:1000. ICC/IF: 0.1 - 2 microg/ml. IHC-P: 1:200 - 1:400. IHC-Fr: 1:400. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Applications
Electron Microscopy, ImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, ImmunoHistoChemistry Paraffin
Certification
Research Use Only
Clonality
Polyclonal
Concentration
1 mg/ml
Conjugate
Unconjugated
Gene ID81631
Target name
MAP1LC3B
Target description
microtubule associated protein 1 light chain 3 beta
Target synonyms
ATG8F, LC3B, MAP1A/1BLC3, MAP1LC3B-a, microtubule-associated protein 1 light chain 3 beta, MAP1 light chain 3-like protein 2, MAP1A/MAP1B LC3 B, MAP1A/MAP1B light chain 3 B, autophagy-related ubiquitin-like modifier LC3 B, microtubule-associated proteins 1A/1B light chain 3B
Host
Rabbit
Isotype
IgG
Protein IDQ9GZQ8
Protein Name
Microtubule-associated protein 1 light chain 3 beta
Scientific Description
The product of this gene is a subunit of neuronal microtubule-associated MAP1A and MAP1B proteins, which are involved in microtubule assembly and important for neurogenesis. Studies on the rat homolog implicate a role for this gene in autophagy, a process that involves the bulk degradation of cytoplasmic component. [provided by RefSeq]
Reactivity
Bovine, Canine, Human, Mouse, Porcine, Primate, Rat, Zebra Fish
Storage Instruction
-20°C or -80°C,2°C to 8°C
UNSPSC
12352203

References

Varga G, Schleifenbaum S, Koenig U, et al. Phagocytic cell death leads to enhanced release of pro-inflammatory S100A12 in familial Mediterranean fever. Mol Cell Pediatr. 2023,10(1):19. doi: 10.1186/s40348-023-00173-3
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Mostafa DK, Nayel OA, Abdulmalek S, et al. Modulation of autophagy, apoptosis and oxidative stress: a clue for repurposing metformin in photoaging. Inflammopharmacology. 2022,30(6):2521-2535. doi: 10.1007/s10787-022-01041-8
Read this paper
Pan X, Taherzadeh M, Bose P, et al. Glucosamine amends CNS pathology in mucopolysaccharidosis IIIC mouse expressing misfolded HGSNAT. J Exp Med. 2022,219(8). doi: 10.1084/jem.20211860
Read this paper
Tsai CH, Lii CK, Wang TS, et al. Docosahexaenoic acid promotes the formation of autophagosomes in MCF-7 breast cancer cells through oxidative stress-induced growth inhibitor 1 mediated activation of AMPK/mTOR pathway. Food Chem Toxicol. 2021,154:112318. doi: 10.1016/j.fct.2021.112318
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Mohapatra S, Chakraborty T, Shimizu S, et al. Estrogen and estrogen receptors chauffeur the sex-biased autophagic action in liver. Cell Death Differ. 2020,27(11):3117-3130. doi: 10.1038/s41418-020-0567-3
Read this paper
Koenig U, Robenek H, Barresi C, et al. Cell death induced autophagy contributes to terminal differentiation of skin and skin appendages. Autophagy. 2020,16(5):932-945. doi: 10.1080/15548627.2019.1646552
Read this paper
Sukseree S, Chen YT, Laggner M, et al. Tyrosinase-Cre-Mediated Deletion of the Autophagy Gene Atg7 Leads to Accumulation of the RPE65 Variant M450 in the Retinal Pigment Epithelium of C57BL/6 Mice. PLoS One. 2016,11(8):e0161640. doi: 10.1371/journal.pone.0161640
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Koenig U, Fobker M, Lengauer B, et al. Autophagy facilitates secretion and protects against degeneration of the Harderian gland. Autophagy. 2015,11(2):298-313. doi: 10.4161/15548627.2014.978221
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Rossiter H, König U, Barresi C, et al. Epidermal keratinocytes form a functional skin barrier in the absence of Atg7 dependent autophagy. J Dermatol Sci. 2013,71(1):67-75. doi: 10.1016/j.jdermsci.2013.04.015
Read this paper
Zhao Y, Zhang CF, Rossiter H, et al. Autophagy is induced by UVA and promotes removal of oxidized phospholipids and protein aggregates in epidermal keratinocytes. J Invest Dermatol. 2013,133(6):1629-37. doi: 10.1038/jid.2013.26
Read this paper

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LC3B antibody

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