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LDL Receptor antibody

Name: LDL Receptor antibody
SKU: GTX132860_G10
Availability: BackOrder

GTX132860

ApplicationsWestern Blot

Product group Antibodies

ReactivityHuman, Rat

TargetLDLR

Overview

Supplier
GeneTex
Product Name
LDL Receptor antibody
Delivery Days Customer
9
Application Supplier Note
WB: 1:500-1:3000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Applications
Western Blot
Certification
Research Use Only
Clonality
Polyclonal
Concentration
0.66 mg/ml
Conjugate
Unconjugated
Gene ID3949
Target name
LDLR
Target description
low density lipoprotein receptor
Target synonyms
FH, FHC, FHCL1, LDLCQ2, low-density lipoprotein receptor, LDL receptor, low-density lipoprotein receptor class A domain-containing protein 3
Host
Rabbit
Isotype
IgG
Protein IDP01130
Protein Name
Low-density lipoprotein receptor
Scientific Description
The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia. [provided by RefSeq]
Reactivity
Human, Rat
Storage Instruction
-20°C or -80°C,2°C to 8°C
UNSPSC
12352203

Panighel G, Ferrarese I, Lupo MG, et al. Investigating the in vitro mode of action of okra (Abelmoschus esculentus) as hypocholesterolemic, anti-inflammatory, and antioxidant food. Food Chem (Oxf). 2022,5:100126. doi: 10.1016/j.fochms.2022.100126
Read this paper
Sut S, Tahmasebi A, Ferri N, et al. NMR, LC-MS Characterization of Rydingia michauxii Extracts, Identification of Natural Products Acting as Modulators of LDLR and PCSK9. Molecules. 2022,27(7). doi: 10.3390/molecules27072256
Read this paper
Sut S, Ferrarese I, Lupo MG, et al. The Modulation of PCSK9 and LDLR by Supercritical CO(2) Extracts of Mentha longifolia and Isolated Piperitone Oxide, an In Vitro Study. Molecules. 2021,26(13). doi: 10.3390/molecules26133886
Read this paper
Lupo MG, Marchianò S, Adorni MP, et al. PCSK9 Induces Rat Smooth Muscle Cell Proliferation and Counteracts the Pleiotropic Effects of Simvastatin. Int J Mol Sci. 2021,22(8). doi: 10.3390/ijms22084114
Read this paper