Lifirafenib

Biorbyt

Lifirafenib [1446090-79-4]

10

1446090-79-4

Research Use Only

98.25%

C25H17F3N4O3

478.42

Lifirafenib (Beigene-283) is a potent inhibitor of RAF family kinases and EGFR in biochemical assays with IC50 of 23, 29 and 495 nM for the recombinant BRAFV600E kinase domain, EGFR and EGFR T790M/L858R mutant respectively.

[H][C@]12Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3[C@@]1([H])[C@@H]2c1nc2ccc(cc2[nH]1)C(F)(F)F

-20°C

12352200