Western blot analysis of extracts from Jurkat cells, using DNL4 antibody.
Western blot analysis of extracts from Jurkat cells, using DNL4 antibody.
LIG4 Antibody
CSB-PA869550
ApplicationsWestern Blot, ELISA
Product group Antibodies
ReactivityHuman
TargetLIG4
Overview
- SupplierCusabio
- Product NameLIG4 Antibody
- Delivery Days Customer20
- ApplicationsWestern Blot, ELISA
- CertificationResearch Use Only
- ClonalityPolyclonal
- ConjugateUnconjugated
- Gene ID3981
- Target nameLIG4
- Target descriptionDNA ligase 4
- Target synonymsDNA joinase; DNA ligase 4; DNA ligase IV; DNA repair enzyme; LIG4S; ligase IV, DNA, ATP-dependent; polydeoxyribonucleotide synthase [ATP] 4; polynucleotide ligase; sealase
- HostRabbit
- IsotypeIgG
- Protein IDP49917
- Protein NameDNA ligase 4
- Scientific DescriptionEfficiently joins single-strand breaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. The LIG4-XRCC4 complex is responsible for the NHEJ ligation step, and XRCC4 enhances the joining activity of LIG4. Binding of the LIG4-XRCC4 complex to DNA ends is dependent on the assembly of the DNA-dependent protein kinase complex DNA-PK to these DNA ends. Wei Y.-F., Mol. Cell. Biol. 15:3206-3216(1995). Dunham A., Nature 428:522-528(2004). Robins P., J. Biol. Chem. 271:24257-24261(1996).
- ReactivityHuman
- Storage Instruction-20°C or -80°C
- UNSPSC12352203