LMAN1 antibody

GeneTex

LMAN1 antibody

9

Western Blot

Research Use Only

Polyclonal

Unconjugated

LMAN1

lectin, mannose binding 1

endoplasmic reticulum-golgi intermediate compartment protein 53; ERGIC53; ERGIC-53; ER-Golgi intermediate compartment 53 kDa protein; F5F8D; FMFD1; gp58; intracellular mannose-specific lectin MR60; MCFD1; MR60; protein ERGIC-53

Chicken

IgY

Protein ERGIC-53

Mannose-specific lectin. May recognize sugar residues of glycoproteins. glycolipids. or glycosylphosphatidyl inositol anchors and may be involved in the sorting or recycling of proteins. lipids. or both. The LMAN1-MCFD2 complex forms a specific cargo receptor for the ER-to-Golgi transport of selected proteins.The protein encoded by this gene is a type I integral membrane protein localized in the intermediate region between the endoplasmic reticulum and the Golgi. presumably recycling between the two compartments. The protein is a mannose-specific lectin and is a member of a novel family of plant lectin homologs in the secretory pathway of animal cells. Mutations in the gene are associated with a coagulation defect. Using positional cloning. the gene was identified as the disease gene leading to combined factor V-factor VIII deficiency. a rare. autosomal recessive disorder in which both coagulation factors V and VIII are diminished.

Human

-20°C or -80°C,2°C to 8°C

12352203