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ProductsBack/LOXL2 antibody

LOXL2 antibody

Research Use Only
GTX105085
GeneTex
ApplicationsImmunoFluorescence, Western Blot, ELISA, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
DownloadDatasheet
Product group Antibodies
ReactivityHuman, Mouse
TargetLOXL2
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Packing Size
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Overview

  • Supplier
    GeneTex
  • Product Name
    LOXL2 antibody
  • Delivery Days Customer
    9
  • Antibody Specificity
    Mouse reactivity has been validated by IHC-P only, not yet been tested by other applications.
  • Applications
    ImmunoFluorescence, Western Blot, ELISA, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    1.02 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID4017
  • Target name
    LOXL2
  • Target description
    lysyl oxidase like 2
  • Target synonyms
    LOR; LOR2; lysyl oxidase homolog 2; lysyl oxidase related 2; lysyl oxidase-like 2 delta e13; lysyl oxidase-like 2 protein; lysyl oxidase-like protein 2; lysyl oxidase-related protein 2; lysyl oxidase-related protein WS9-14; WS9-14
  • Host
    Rabbit
  • Isotype
    IgG
  • Scientific Description
    This gene encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family. [provided by RefSeq]
  • Reactivity
    Human, Mouse
  • Storage Instruction
    2°C to 8°C,-20°C or -80°C
  • UNSPSC
    12352203

References

  • Reciprocal regulation of LOXL2 and HIF1alpha drives the Warburg effect to support pancreatic cancer aggressiveness. Li R et al., 2021 Nov 26, Cell Death Dis
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  • The Expression Patterns and Roles of Lysyl Oxidases in Aortic Dissection. Yi X et al., 2021, Front Cardiovasc Med
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  • MIR29A Impedes Metastatic Behaviors in Hepatocellular Carcinoma via Targeting LOX, LOXL2, and VEGFA. Yang YL et al., 2021 Jun 1, Int J Mol Sci
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  • Microarray expression profile of mRNAs and long noncoding RNAs and the potential role of PFK-1 in infantile hemangioma. Yang K et al., 2021 Jan 11, Cell Div
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  • LOXL2 promotes aggrecan and gender-specific anabolic differences to TMJ cartilage. Tashkandi MM et al., 2020 Nov 19, Sci Rep
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  • Mechanical injury and IL-1beta regulated LOXs and MMP-1, 2, 3 expression in ACL fibroblasts co-cultured with synoviocytes. Wang C et al., 2020 Aug, Biotechnol Lett
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  • LOXL2 Expression Status Is Correlated With Molecular Characterizations of Cervical Carcinoma and Associated With Poor Cancer Survival via Epithelial-Mesenchymal Transition (EMT) Phenotype. Cao C et al., 2020, Front Oncol
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  • Withaferin A reverses bile duct ligation-induced liver fibrosis by modulating extracellular matrix deposition: Role of LOXL2/Snail1, vimentin, and NFkappaB signaling. Sayed N et al., 2019 Jul 23, Biofactors
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  • Mechanism for oral tumor cell lysyl oxidase like-2 in cancer development: synergy with PDGF-AB. Mahjour F et al., 2019 May 13, Oncogenesis
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  • Aberrant Collagen Cross-linking in Human Oral Squamous Cell Carcinoma. Saito T et al., 2019 May, J Dent Res
    Read more