LOXL2 antibody
GTX105085
ApplicationsImmunoFluorescence, Western Blot, ELISA, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman, Mouse
TargetLOXL2
Overview
- SupplierGeneTex
- Product NameLOXL2 antibody
- Delivery Days Customer9
- Antibody SpecificityMouse reactivity has been validated by IHC-P only, not yet been tested by other applications.
- Application Supplier NoteWB: 1:500-1:10000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- ApplicationsImmunoFluorescence, Western Blot, ELISA, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
- CertificationResearch Use Only
- ClonalityPolyclonal
- Concentration1.02 mg/ml
- ConjugateUnconjugated
- Gene ID4017
- Target nameLOXL2
- Target descriptionlysyl oxidase like 2
- Target synonymsLOR; LOR2; lysyl oxidase homolog 2; lysyl oxidase related 2; lysyl oxidase-like 2 delta e13; lysyl oxidase-like 2 protein; lysyl oxidase-like protein 2; lysyl oxidase-related protein 2; lysyl oxidase-related protein WS9-14; WS9-14
- HostRabbit
- IsotypeIgG
- Protein IDQ9Y4K0
- Protein NameLysyl oxidase homolog 2
- Scientific DescriptionThis gene encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family. [provided by RefSeq]
- ReactivityHuman, Mouse
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203
References
- Pharmacological targeting of the mitochondrial calcium-dependent potassium channel KCa3.1 triggers cell death and reduces tumor growth and metastasis in vivo.Read more
- Reciprocal regulation of LOXL2 and HIF1alpha drives the Warburg effect to support pancreatic cancer aggressiveness. Li R et al., 2021 Nov 26, Cell Death DisRead more
- The Expression Patterns and Roles of Lysyl Oxidases in Aortic Dissection. Yi X et al., 2021, Front Cardiovasc MedRead more
- MIR29A Impedes Metastatic Behaviors in Hepatocellular Carcinoma via Targeting LOX, LOXL2, and VEGFA. Yang YL et al., 2021 Jun 1, Int J Mol SciRead more
- Microarray expression profile of mRNAs and long noncoding RNAs and the potential role of PFK-1 in infantile hemangioma. Yang K et al., 2021 Jan 11, Cell DivRead more
- LOXL2 promotes aggrecan and gender-specific anabolic differences to TMJ cartilage. Tashkandi MM et al., 2020 Nov 19, Sci RepRead more
- Mechanical injury and IL-1beta regulated LOXs and MMP-1, 2, 3 expression in ACL fibroblasts co-cultured with synoviocytes. Wang C et al., 2020 Aug, Biotechnol LettRead more
- LOXL2 Expression Status Is Correlated With Molecular Characterizations of Cervical Carcinoma and Associated With Poor Cancer Survival via Epithelial-Mesenchymal Transition (EMT) Phenotype. Cao C et al., 2020, Front OncolRead more
- Withaferin A reverses bile duct ligation-induced liver fibrosis by modulating extracellular matrix deposition: Role of LOXL2/Snail1, vimentin, and NFkappaB signaling. Sayed N et al., 2019 Jul 23, BiofactorsRead more
- Mechanism for oral tumor cell lysyl oxidase like-2 in cancer development: synergy with PDGF-AB. Mahjour F et al., 2019 May 13, OncogenesisRead more