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LOXL2 antibody

GTX105085
GeneTex
ApplicationsImmunoFluorescence, Western Blot, ELISA, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
TargetLOXL2
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Overview

  • Supplier
    GeneTex
  • Product Name
    LOXL2 antibody
  • Delivery Days Customer
    9
  • Application Supplier Note
    WB: 1:500-1:10000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    ImmunoFluorescence, Western Blot, ELISA, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    1.02 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID4017
  • Target name
    LOXL2
  • Target description
    lysyl oxidase like 2
  • Target synonyms
    LOR, LOR2, WS9-14, lysyl oxidase homolog 2, lysyl oxidase related 2, lysyl oxidase-like 2 delta e13, lysyl oxidase-like 2 protein, lysyl oxidase-like protein 2, lysyl oxidase-related protein 2, lysyl oxidase-related protein WS9-14
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDQ9Y4K0
  • Protein Name
    Lysyl oxidase homolog 2
  • Scientific Description
    This gene encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family. [provided by RefSeq]
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • Bachmann M, Rossa A, Varanita T, et al. Pharmacological targeting of the mitochondrial calcium-dependent potassium channel KCa3.1 triggers cell death and reduces tumor growth and metastasis in vivo. Cell Death Dis. 2022,13(12):1055. doi: 10.1038/s41419-022-05463-8
    Read this paper
  • Li R, Li H, Zhu L, et al. Reciprocal regulation of LOXL2 and HIF1α drives the Warburg effect to support pancreatic cancer aggressiveness. Cell Death Dis. 2021,12(12):1106. doi: 10.1038/s41419-021-04391-3
    Read this paper
  • Yi X, Zhou Y, Chen Y, et al. The Expression Patterns and Roles of Lysyl Oxidases in Aortic Dissection. Front Cardiovasc Med. 2021,8:692856. doi: 10.3389/fcvm.2021.692856
    Read this paper
  • Yang YL, Tsai MC, Chang YH, et al. MIR29A Impedes Metastatic Behaviors in Hepatocellular Carcinoma via Targeting LOX, LOXL2, and VEGFA. Int J Mol Sci. 2021,22(11). doi: 10.3390/ijms22116001
    Read this paper
  • Yang K, Zhang X, Chen L, et al. Microarray expression profile of mRNAs and long noncoding RNAs and the potential role of PFK-1 in infantile hemangioma. Cell Div. 2021,16(1):1. doi: 10.1186/s13008-020-00069-y
    Read this paper
  • Tashkandi MM, Alsaqer SF, Alhousami T, et al. LOXL2 promotes aggrecan and gender-specific anabolic differences to TMJ cartilage. Sci Rep. 2020,10(1):20179. doi: 10.1038/s41598-020-77178-9
    Read this paper
  • Wang C, Chi Q, Sha Y, et al. Mechanical injury and IL-1β regulated LOXs and MMP-1, 2, 3 expression in ACL fibroblasts co-cultured with synoviocytes. Biotechnol Lett. 2020,42(8):1567-1579. doi: 10.1007/s10529-020-02870-9
    Read this paper
  • Cao C, Lin S, Zhi W, et al. LOXL2 Expression Status Is Correlated With Molecular Characterizations of Cervical Carcinoma and Associated With Poor Cancer Survival via Epithelial-Mesenchymal Transition (EMT) Phenotype. Front Oncol. 2020,10:284. doi: 10.3389/fonc.2020.00284
    Read this paper
  • Sayed N, Khurana A, Saifi MA, et al. Withaferin A reverses bile duct ligation-induced liver fibrosis by modulating extracellular matrix deposition: Role of LOXL2/Snail1, vimentin, and NFκB signaling. Biofactors. 2019,45(6):959-974. doi: 10.1002/biof.1546
    Read this paper
  • Mahjour F, Dambal V, Shrestha N, et al. Mechanism for oral tumor cell lysyl oxidase like-2 in cancer development: synergy with PDGF-AB. Oncogenesis. 2019,8(5):34. doi: 10.1038/s41389-019-0144-0
    Read this paper

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