Lymphotactin antibody

GeneTex

Lymphotactin antibody

9

The antibody will neutralize the biological activity of human lymphotactin.

WB: 1-2 microg/ml. ELISA: 0.5-1.0 microg/mL. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

Western Blot, ELISA, Neutralisation/Blocking

Research Use Only

Polyclonal

Unconjugated

XCL1

X-C motif chemokine ligand 1

ATAC; c motif chemokine 1; chemokine (C motif) ligand 1; cytokine SCM-1; LPTN; LTN; lymphotactin; lymphotaxin; SCM1; SCM-1; SCM1A; SCM-1a; SCM-1-alpha; SCYC1; single cysteine motif 1a; small inducible cytokine subfamily C, member 1 (lymphotactin); small-inducible cytokine C1; XC chemokine ligand 1

Goat

IgG

Lymphotactin

Human lymphotactin (Lptn)/XCL1, also named human SCM1 and ATAC, is a member of gamma or C subfamily of chemokines that lack two of the four invariant cysteine residues normally found in the CC and CXC chemokines and have an extended C-terminus. Human lymphotactin encodes a 114 amino acid precursor protein with a 21 amino acid predicted signal peptide. The gene for human and mouse lymphotactin has been mapped to chromosome 1. Human and mouse lymphotactin share approximately 60% amino acid sequence identity.The expression of lymphotactin is restricted to activated T cells such as activated CD8+ T cells and other class I MHC restricted T cells. Since lymphotactin is produced by lymphocytes and acts on lymphocytes, it is speculated that it is a messenger in T cell chemoattraction. Human lymphotactin is chemotactic for lymphocytes and NK cells. Its expression is abundant in some activated T cells such as activated CD8+ T cells and other class I MCH restricted T cells and is absent in CD4+ T cells. It has been shown that lymphotactin is a key regulator of lymphocyte motility and adhesion during acute allograft rejection. The specific receptor for lymphotactin is the orphan receptor XCR1 (GPR5).

Human

-20°C or -80°C,2°C to 8°C

12352203